# www.betterbrain.com > llms-full.txt for https://www.betterbrain.com — 50 pages, summaries, generated 2026-06-28 ## Blog ### Cholesterol and Your Brain: What You Actually Need to Know Source: https://www.betterbrain.com/articles/cholesterol-and-your-brain-what-you-actually-need-to-know Description: Your brain holds 25% of your body's cholesterol. Learn why apoB matters more than LDL, how brain cholesterol works separately from blood cholesterol, and what it means for Alzheimer's risk. Cholesterol and Your Brain: What You Actually Need to KnowFebruary 16, 2026Read time:5 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:Cholesterol gets a bad rap. For decades, we've heard that it clogs arteries and causes heart attacks. But here's what doesn't make headlines: your brain contains 25% of your body's total cholesterol despite making up only 2% of your body weight. As lipid expert Dr. Tom Dayspring puts it, "Cholesterol is almost certainly the most important molecule in the brain."So how can cholesterol be both necessary for brain function and a major cardiovascular risk factor? The answer lies in understanding where cholesterol is, how it gets there, and what form it takes.In this post, we're taking a deeper dive into cholesterol than usual. We'll break down what your cholesterol numbers actually mean, why the standard tests miss critical information, and how the cholesterol story connects cardiovascular health to brain health.The Basics: What Is Cholesterol?Cholesterol is a fatty molecule that serves critical functions throughout your body. It forms the outer layer of every cell, helps produce hormones (including testosterone, estrogen, and cortisol), enables vitamin D synthesis, and supports nerve function. Without cholesterol, you simply couldn't survive.But there's an important distinction to make: "cholesterol" isn't one thing.When we talk about cholesterol in the blood versus cholesterol in the brain, we're really talking about two separate systems that operate differently.Blood cholesterol: Cholesterol travels through your bloodstream inside particles called lipoproteins. These particles come in different types:LDL (low-density lipoprotein): Often called "bad" cholesterol, LDL particles deliver cholesterol to cells throughout your bodyHDL (high-density lipoprotein): Called "good" cholesterol, HDL particles help transport excess cholesterol back to the liverVLDL (very low-density lipoprotein): Primarily transports triglycerides but also carries some cholesterolIDL (intermediate-density lipoprotein): A transition form between VLDL and LDLBrain cholesterol: Your brain makes its own cholesterol and keeps… --- ### Clearing the Air: How Pollution Influences Alzheimer's Risk Source: https://www.betterbrain.com/articles/clearing-the-air-how-pollution-influences-alzheimers-risk Description: Air pollution may elevate Alzheimer's risk. Luckily, there are many proven strategies to protect your lungs and your brain from chronic exposure. Clearing the Air: How Pollution Influences Alzheimer's RiskOctober 17, 2023Read time:3 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:Long-term exposure to fine particulate air pollution (PM2.5) is associated with an increased risk of Alzheimer's disease. This extends the importance of air quality control to brain health and underscores the importance of personal protective measures like using air purifiers, wearing masks, and staying inside on high pollution days.When you think of air pollution, respiratory disease is usually the first thing to come to mind. However, recent findings from the Emory Healthy Brain Study1 has begun to show that long-term exposure to tiny particles called PM2.5 has been associated with the accumulation of amyloid plaques in the brain, which is a hallmark of Alzheimer's disease. While this doesn't prove that PM2.5 exposure leads to Alzheimer's, it suggests a potentially elevated risk, especially among those exposed to poor quality air over longer periods of time.Air quality is typically measured by the amount of specific pollutants in the air. The Emory Healthy Brain Study looked at a type of pollutant called PM2.5, which is fine particulate matter with a diameter of less than 2.5 micrometers (about 30 times smaller than a human hair). These particles are so fine they can bypass the body's airway defenses and enter the bloodstream. Common sources of PM2.5 include vehicle emissions, industrial combustion, and natural occurrences like wildfires. Because the particles can enter the bloodstream, they can cause health issues that go beyond simple respiratory irritation, potentially affecting brain health and contributing to cognitive decline.‍Key Findings from the StudyIncreased PM2.5 exposure is associated with worse results on Alzheimer’s pathology biomarkers: The study indicated that higher levels of PM2.5 exposure over one and three years are associated with lower concentrations of amyloid-beta 42 (Aβ42) in cerebrospinal fluid (CSF). Aβ42 is a biomarker… --- ### Dietary Defenders: Prebiotic Fibers in Alzheimer's Prevention Source: https://www.betterbrain.com/articles/dietary-defenders-the-role-of-prebiotic-fibers-in-alzheimers-prevention Description: Research links the gut-brain axis to cognitive health, suggesting dietary fiber improves brain function and may reduce Alzheimer's risk. Dietary Defenders: Prebiotic Fibers in Alzheimer's PreventionApril 3, 2024Read time:6 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:Increased dietary consumption of prebiotic fibers can boost the presence of healthy gut bacteria, which has been linked to improved cognitive function and may potentially improve dementia prognosis.As Alzheimer's disease continues to impact millions globally, the scientific community is increasingly focusing on the gut-brain axis. This complex communication network, which links the gastrointestinal tract and the brain, could play a major role in preventing cognitive decline. Recent discoveries1 have shown that gut microbiota might affect everything from brain development to behavior to disease states, and researchers are starting to explore how the gut-brain axis can influence dementia risk.‍Exploratory study: A closer look at fiber's impact on aging brainsThe School of Life Course & Population Sciences at King’s College London spearheaded a pivotal double-blind study2 (the same type of study as used for clinical trials) with participants over 60 years old. Their research aimed to uncover the cognitive effects of consuming prebiotic fibers compared to a placebo.‍Fiber fuels cognitive fortitudeLike any organism, the components making up the gut microbiome need food to survive. One source of nutrients for them is prebiotic fibers, such as inulin and fructooligosaccharides (FOS), both of which were the focus of the King’s College study. The researchers found that participants who took prebiotic supplements had more of one species of healthy bacteria called Bifidobacterium in their gut. This species has previously been linked to better cognitive performance, and indeed the participants who took supplements showed improved cognitive function scores through the same memory tests that are used as an early indicator of Alzheimer’s disease.‍Why is this happening? The composition of the gut microbiome has drastically changed over human history. Advances in agriculture, industrialization and globalization may have caused a decrease in gut microbial… --- ### Fighting Dementia with CBT: A proactive approach Source: https://www.betterbrain.com/articles/fighting-dementia-with-cbt-a-proactive-approach Description: CBT can help prevent dementia by reducing mental illness and promoting healthy habits Fighting Dementia with CBT: A proactive approachDecember 3, 2023Read time:7 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:CBT can help proactively combat Alzheimer’s by reshaping behaviors and thought patterns linked to key lifestyle risks, fostering cognitive health.Cognitive-behavioral therapy (CBT) has long been recognized as a powerful tool in managing mental health disorders, but its potential role in preventing dementia is only beginning to be appreciated1,2. There are two ways that CBT can help. First, CBT is a powerful tool which can combat anxiety, depression, and other mental health disorders, which increase the risk of dementia3,4. Second, CBT can be used to facilitate habit change - that is to say, help users adopt behaviors which promote brain health.‍How does CBT work? CBT is a structured form of psychotherapy that relies on the principle of identifying and changing certain thought patterns and behaviors. The underlying principle is that the brain is “plastic” or flexible throughout life, which means that we can shape the connections our brain makes. The therapy is collaborative, with the client and therapist working together to set goals and practice new skills. The specifics of a CBT session will vary depending on the needs of each individual, but sessions generally involve recognizing distorted thinking, challenging irrational beliefs, and developing healthier responses. CBT also encourages behavioral changes by gradually facing fears or engaging in positive activities.‍CBT in Alzheimer’s preventionCombating mental illnessYour mental health is closely linked to your brain health. Depression, anxiety, and other disorders can actually increase inflammatory stress in your brain and disrupt your cognitive function. There are several different approaches to treating mental illness, and CBT happens to be highly effective for some people. ‍Forming healthy habitsMuch of dementia prevention relies on addressing known lifestyle risk factors, things like physical inactivity, poor diet, diabetes, and high blood pressure. Forming and maintaining… --- ### Harnessing Heart Rate Variability for Brain Health Source: https://www.betterbrain.com/articles/harnessing-heart-rate-variability-for-brain-health-and-dementia-prevention Description: HRV impacts brain health, emotional regulation, and cognitive function, making HRV training a promising method for dementia prevention. Harnessing Heart Rate Variability for Brain HealthFebruary 4, 2024Read time:4 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:Harnessing heart rate variability (HRV) through biofeedback techniques can significantly enhance brain health and emotional regulation, offering promising pathways for dementia prevention.The intricate dance between our heart rate and brain function is more influential than we might think. Recent studies reveal that heart rate variability (HRV)—the measure of variations between individual heartbeats—affects our brain health, decision-making abilities, and even our emotional regulation. HRV is a physiological metric that we can train ourselves to improve, and its connections to the brain make HRV training a promising technique for dementia prevention and enhancing cognitive function.‍Understanding the Heart-Brain Connection:While your heart rate is the average number of beats per minute, HRV is the difference in length between individual heartbeats. HRV is not just a measure of heart health - it reflects the health and balance of the autonomic nervous system (ANS), which is responsible for involuntary body functions. In particular, HRV serves as a key indicator of the interaction between the two components of the ANS: the sympathetic (fight or flight) and parasympathetic (rest and digest) nervous systems. Interestingly, there is a two-way feedback system between these nervous systems and the heart. The signals from the sympathetic and parasympathetic influence heart rate, and heart rate regulates the balance of these two systems. By exerting an influence on the ANS, heart rate variability helps regulate emotions and stress responses. In general, higher HRV is associated with better control over decision-making processes, emotional responses, anxiety, and social behaviors1.‍Booting your HRVCommon HRV training protocols call for biofeedback, which is a fancy way of saying you need a sensor to measure your heart rate variability so you can improve it. HRV training involves guided exercises such as paced breathing while looking at real-time… --- ### hs-CRP: The Biomarker Most Likely to Flag Silent Inflammation in Brain Health Source: https://www.betterbrain.com/articles/hs-crp-the-biomarker-most-likely-to-flag-silent-inflammation-in-brain-health Description: hs-CRP: The Biomarker Most Likely to Flag Silent Inflammation in Brain Health hs-CRP: The Biomarker Most Likely to Flag Silent Inflammation in Brain HealthMay 26, 2026Read time:5 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:hs-CRP (high-sensitivity C-reactive protein) detects chronic low-grade inflammation, the kind associated with long-term cognitive decline. Standard CRP, which most routine panels use, is designed to detect acute inflammation and misses the chronic version. The 1.0 to 3.0 mg/L range is where many clients quietly run elevated. Most labs flag a result only when it crosses 3.0, leaving the brain-health-relevant range unaddressed. hs-CRP becomes most useful in context. Pair it with homocysteine, ApoB, HbA1c, fasting insulin, and ferritin to see whether the inflammation is metabolic, vascular, or nutrient-driven.If you have ever had a routine blood panel, you have probably seen "CRP" on the list. What you may not have seen is "hs-CRP," which sounds like the same test but is not. The difference matters a lot for brain health.This piece walks through what hs-CRP measures, why it shows up in almost every BetterBrain protocol, and what to do if yours is elevated.What hs-CRP measuresC-reactive protein is made by your liver in response to inflammation anywhere in your body. The "hs" stands for "high-sensitivity," which means the test can detect very low levels of CRP that the standard CRP test cannot.This distinction sounds technical but it is the whole reason we use hs-CRP and not standard CRP. Standard CRP is designed to spot acute inflammation, like an active infection or a recent injury. The values it flags are high enough to indicate something is actively wrong right now. hs-CRP is designed to spot chronic low-grade inflammation, the kind that does not feel like anything but is associated with long-term risk for cardiovascular disease, type 2 diabetes, and cognitive decline.For brain health, the chronic low-grade version is the one that matters.Why this matters… --- ### Metabolic Syndrome as a Gateway to Dementia Source: https://www.betterbrain.com/articles/metabolic-syndrome-as-a-gateway-to-dementia Description: Metabolic syndrome, a precursor to diabetes, significantly increases dementia risk. Small lifestyle changes can improve metabolic health and help prevent cognitive decline. Metabolic Syndrome as a Gateway to DementiaMarch 17, 2024Read time:6 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:Managing metabolic syndrome—characterized by obesity, high blood pressure, high blood sugar, and abnormal cholesterol—can significantly reduce the risk of dementia, emphasizing the crucial link between metabolic health and brain health.It’s a well-known fact that Alzheimer’s disease is closely linked to metabolic health, to the point that some experts have begun to refer to it as Type III Diabetes. But what many people don’t know is that poor metabolic health is a strong risk factor for dementia long before it progresses to diabetes, even for people without a family history.‍Decoding metabolic syndromeBefore you get diagnosed with diabetes, your body goes through a number of changes. Cells in your body become desensitized to insulin, which usually tells them to absorb sugar from your bloodstream. This results in chronically elevated blood sugar and in turn starts causing problems for your heart, liver, brain, and other organs. This pre-diabetic phase is called metabolic syndrome, and it affects ~25% of adults worldwide, including 40% adults aged 60+ in the U.S. Most of them do not know that metabolic syndrome is a health risk. ‍Metabolic syndrome is diagnosed when an individual has three or more of the following: High triglycerides (≥150 mg/dL)Elevated blood pressure (≥130 mmHg systolic or ≥85 mmHg diastolic) OR use of antihypertensive medicationHigh fasting glucose (≥100 mg/dL OR use of glucose lowering medications)Low HDL cholesterol (<40 mg/dL in men; <50 mg/dL in women OR use of lipid-modifying medication)Abdominal obesity (waist circumference ≥102 cm for men and ≥88 cm for women)It’s worth noting that hemoglobin A1c (HbA1c), a common marker for diabetes, does not feature on this list. Although a doctor won’t use A1c to diagnose metabolic syndrome, it’s still an important marker to keep track of your metabolic health.‍Connecting metabolic… --- ### Rapamycin: Revolutionizing Alzheimer's Prevention? Source: https://www.betterbrain.com/articles/rapamycin-revolutionizing-longevity-and-alzheimers-prevention Description: Rapamycin shows promise in longevity and Alzheimer's prevention by inhibiting mTOR, though we need more human trail evidence Rapamycin: Revolutionizing Alzheimer's Prevention?June 13, 2024Read time:5 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:Rapamycin is a drug that shows lots of potential to extend lifespan and reduce Alzheimer’s risk. Although its long-term effects are still being investigated and the FDA has only cleared it for immunosuppression, many already use it “off-label” for lifespan extension.In the 1960s, researchers on Easter Island were investigating local indigenous peoples’ claims that the soil has healing properties. After testing various soil samples, the researchers isolated a small molecule they believed was responsible for the effects. They named it rapamycin5, after the traditional name for the island, Rapa Nui. Since its discovery, rapamycin has been used in various settings, from an antifungal agent to more recently a beacon of hope in anti-aging medicine. Additionally, it is showing promise in extending lifespan and preventing neurodegenerative diseases such as Alzheimer’s.‍From anti-rejection med to longevity enhancerThe transition from an antifungal to a potential longevity drug has been intriguing. Rapamycin, approved in 1999 for its immunosuppressant qualities, is still commonly used in kidney transplants to prevent organ rejection. However, a 2014 study1 on older adults revealed a paradox: at much smaller doses, rapamycin boosted the immune response to flu vaccinations, despite their age-related weakened immune function. This unexpected enhancement suggests that rapamycin might have broader applications for disease prevention in older adults, potentially making it a valuable tool in combating age-related declines in the human immune system.‍How rapa worksTo understand how rapamycin works, it’s important to understand the molecule that it targets: a cellular receptor named mTOR. mTOR is present in nearly all cells in the human body and is responsible for mediating pathways that regulate cell growth, metabolism, and survival.  Inhibiting mTOR completely is catastrophic - it prevents cells from making energy, eventually leading to their death. However, partial inhibition… --- ### Saunas and Alzheimer's: Hot Topic or Just Hot Air? Source: https://www.betterbrain.com/articles/saunas-and-alzheimers-risk Description: The idea that saunas can "burn away" Alzheimer's risk is intriguing but not a standalone solution. While studies show a link, saunas aren't a guaranteed prevention method. Saunas and Alzheimer's: Hot Topic or Just Hot Air?August 10, 2023Read time:3 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:For centuries, saunas have been lauded for their supposed health benefits, from improved cardiovascular function to detoxification. The recent trends around longevity seem to have revitalized the use of saunas, now considered a popular "health hack". But could spending time in these heated chambers also benefit your brain? Recent research suggests that sauna use might indeed play a role in mitigating the risk of Alzheimer's disease. In this article, we'll explore the scientific evidence behind this claim and consider how sauna use may impact your brain health.‍The Connection Between Saunas and Alzheimer's DiseaseThe Finnish StudyA study from Finland has brought attention to the potential benefits of saunas for brain health. According to the 2,315 person study1, men who used a sauna 4-7 times a week showed a 65% reduced risk of Alzheimer's disease compared to those who used it once a week. Although the study mainly focused on men and thus requires further exploration for generalization, the findings are promising - 65% is a staggering number. If true, this would imply we could cut Alzheimer's prevalence from 6 million to 2 million in the US if only everyone used the sauna daily!The Underlying MechanismsScientists have proposed several mechanisms through which saunas may benefit the brain. One suggestion is that saunas can significantly improve sleep quality and time in deep sleep, which improves the brain's ability to clear toxic proteins. Moreover, heat stress activates heat shock proteins that can repair damaged proteins, which may play a role in neurodegenerative diseases like Alzheimer's. Lastly, saunas may improve various markers of vascular function, such as blood pressure and blood circulation, known risk factors for Alzheimer's.Caveats and ConsiderationsFirst, the impact was more muted for those who used… --- ### Should you get tested for APOE4? Source: https://www.betterbrain.com/articles/should-you-get-tested-for-apoe4 Description: Choosing whether to undergo APOE4 testing is a deeply personal decision that should be based on multiple factors including your emotional readiness Should you get tested for APOE4?June 5, 2023Read time:4 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:Chance are, you know someone who has tested for their APOE genotype. With the advent of consumer genotyping companies such as 23andme, genetic testing for Alzheimer's risk has become increasingly accessible, with the APOE4 gene variant taking center stage in the discussion. The question that many people are asking is: Should I get tested for APOE4? This article aims to provide a balanced perspective, detailing the pros and cons to help you make an informed decision.‍What Is APOE4?The APOE gene produces a protein essential for fat metabolism and is involved in brain cell repair. There are three main variants of this gene—APOE2, APOE3, and APOE4—with the APOE4 variant being strongly associated with an increased risk of developing Alzheimer's disease. While having this gene variant doesn't guarantee that you'll develop Alzheimer's, it can significantly elevate your risk. 20-25% of people have 1 copy of APOE4, conferring a 2-3X increase in Alzheimer's risk, while 2-3% of people have 2 copies, which implies an 8-10X increase in risk.‍Advantages of APOE4 TestingEmpowers You to Make Informed ChoicesPerhaps the most compelling reason for getting tested is the ability to make informed decisions about your health. There are specific recommendations for those carrying APOE4 such as significantly increasing DHA consumption given impaired absorption. Additionally, research suggests that APOE4 carriers get even more benefit from a range of interventions than non-carriers. In fact, some experts suggest that by applying the right interventions, you can completely mitigate the impact of having a copy of APOE4.Opens opportunities for clinical trials and futures therapiesThere is a significant research focus on APOE4 and potential pharmacological approaches to mitigating the associated risk. Testing may open up avenues for participating in such trials. Furthermore, as therapies get approved in… --- ### Strength Training and Brain Health: What 6 Months of Lifting Does to Your Hippocampus Source: https://www.betterbrain.com/articles/strength-training-brain-health Description: A 2025 meta-analysis compared every type of exercise for cognitive benefit. Resistance training came out on top. Here's what the brain data actually shows. Strength Training and Brain Health: What 6 Months of Lifting Does to Your HippocampusApril 30, 2026Read time:5MEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:Strength Training and Brain Health: What 6 Months of Lifting Does to Your HippocampusAerobic exercise gets most of the brain-health attention. The cardiovascular benefits are well-documented, the GPLD1 pathway connecting movement to blood-brain barrier repair is real, and almost every brain health protocol recommends it.But a body of research has been quietly building on a different type of exercise entirely. And a comprehensive 2025 network meta-analysis just made the case for strength training impossible to ignore.What the research foundThe analysis, published in Frontiers in Aging Neuroscience, pulled data from dozens of randomized controlled trials involving cognitively healthy older adults. When researchers compared aerobic exercise, resistance training, mind-body practices like yoga, and combined programs for their effect on cognitive function, resistance training produced the strongest overall effect on global cognition. The effect size was considered moderate to large in cognitive research, where meaningful improvements are notoriously difficult to achieve.A parallel 2025 systematic review went further. It examined actual brain imaging alongside cognitive testing. The findings: at least two resistance training sessions per week, sustained for at least six months, were associated with measurable increases in cortical thickness in two critical brain regions.The hippocampus, your brain's primary memory formation center. And the prefrontal cortex, involved in planning, complex reasoning, and self-control. These are precisely the regions most vulnerable to aging and most associated with early cognitive decline.These weren't just improvements in test scores. These were structural changes in brain tissue, visible on MRI scans. Six months of consistent strength training literally changed the physical structure of participants' brains.How it worksThe mechanisms connecting resistance training to brain health are distinct from aerobic exercise benefits, which is exactly why both matter.When your skeletal… --- ### The Essential Techniques our coaches keep recommending for brain health Source: https://www.betterbrain.com/articles/the-essential-techniques-our-coaches-keep-recommending-for-brain-health The Essential Techniques our coaches keep recommending for brain healthMay 21, 2026Read time:5 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:BetterBrain's clinical advisor panel has identified a set of Essential Techniques: the interventions with the greatest evidence and broadest applicability for long-term brain health. A personalized action plan draws from the full technique library, prioritizing among the Essentials (about 15-20% of the library) and layering in context-dependent techniques (the other 80-85%) based on each client's panel and life. Across our coaching team, four Essential Techniques keep coming up most often: the post-meal walk, a consistent wake time with morning light, strength training, and methylated B-complex supplementation.We use the term Essential Techniques inside BetterBrain a lot. Each BetterBrain Practice (Move, Sleep, Eat, De-Stress, and so on) is made up of specific techniques, and the Essential Techniques are the ones our panel of clinical advisors identified as the techniques with the greatest evidence and broadest applicability.These are not techniques for a specific kind of client. They are the techniques worth considering for almost everyone thinking about long-term brain health, regardless of starting point, age, or risk profile. About 15 to 20 percent of the techniques in our library are Essential. The other 80 to 85 percent are context-dependent, applied when a client's panel or situation calls for them. A coach builds a personalized action plan by looking across the whole library, deciding which Essentials to elevate first and which context-dependent techniques to layer in. The Essentials are the foundation underneath every plan.We asked some of our coaches what trends they are seeing across the clients they work with, and which Essential Techniques those trends keep pointing back to.The post-meal walk (Move Practice)Maggie works with clients across the metabolic-health side of our client base. The trend she keeps seeing: HbA1c and fasting insulin numbers creeping… --- ### The Glymphatic System: Why Deep Sleep Is Your Brain's Best Cleanup Tool Source: https://www.betterbrain.com/articles/the-glymphatic-system-why-deep-sleep-is-your-brains-best-cleanup-tool The Glymphatic System: Why Deep Sleep Is Your Brain's Best Cleanup ToolJune 9, 2026Read time:5MEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:What if the most important thing you could do for your brain tonight was also the most straightforward? Not a new supplement or a complicated protocol. Just better sleep, specifically the deep stages most people shortchange without knowing it.Here is the biology that makes that matter more than most people appreciate.Your brain has its own plumbing. It only fully runs at night.Every other tissue in your body has a lymphatic system to carry away metabolic waste. For a long time, the brain was thought to be the exception, with no obvious mechanism for the job. That changed in 2013 when researchers described the glymphatic system: a network that uses cerebrospinal fluid to flush waste out of brain tissue, including amyloid-beta and tau, the proteins that accumulate in Alzheimer's disease.The connection to sleep came alongside it. Glymphatic clearance is not constant. It ramps up dramatically during deep, slow-wave sleep, when the spaces between brain cells expand and fluid can move through more freely. This is one of the clearest biological explanations for why sleep is not optional maintenance. It is when a specific, measurable cleanup process actually runs, protecting your brain now and building resilience for decades to come.What the newer research tells us about the engineThe system's existence has been well established for over a decade. What researchers kept working on was the mechanics: what physically moves the fluid?A 2025 study published in Cell from Maiken Nedergaard's lab (one of the teams behind the original glymphatic work) helps answer that. In mice, the team found that during deep sleep a small brainstem region called the locus coeruleus releases norepinephrine in slow, rhythmic waves, roughly one every fifty seconds. Each wave gently… --- ### The Rise of Amyloid Blood Tests Source: https://www.betterbrain.com/articles/the-rise-of-amyloid-blood-tests Description: The emergence of amyloid (and tau) blood tests is an exciting development in the field of Alzheimer's research and prevention. The Rise of Amyloid Blood TestsMay 10, 2023Read time:5 minMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:The Landscape of Alzheimer's BiomarkersWhen it comes to assessing the risk of cardiovascular disease, we have straightforward biomarkers such as ApoB (LDL) and blood pressure which can predict risk fairly accurately. However, the realm of neurodegenerative diseases like Alzheimer's is a lot more messy. For years, researchers and clinicians have depended PET scans or cerebral spinal fluid (CSF) for analyzing biomarkers like amyloid and tau proteins. But these procedures are expensive ($5-10K in the case of PET) or invasive (CSF requires a lumbar puncture), making them impractical for widespread use.Enter blood amyloid tests, a relatively new but promising diagnostic aimed at solving this problem.‍What Are Blood Amyloid Tests and How Do They Work?As the name suggests, these tests measure the concentration of various amyloid beta proteins in the blood (and sometimes tau as well) as a proxy for amyloid deposition in the brain. While the scientific community continues to debate whether amyloid pathology is a root cause of Alzheimer's disease or merely a symptom of other underlying brain pathologies, there is a clear association between the extent of amyloid presence in the brain and the manifestation of the disease.One of the original commercially available tests was PrecivityAD by C2N. This test needs to be ordered by a physician and was designed to predict the likelihood of Alzheimer's Disease (AD) pathology by analyzing a few key factors:The ratio of two variants of amyloid beta proteins, specifically amyloid beta 42 and amyloid beta 40The ApoE variant of the patientThe age of the individualBy amalgamating these variables, the test attempts to gauge the probability of a positive PET scan. While it's too early to draw any definitive conclusions, there are two primary reasons why looking at this data could… --- ### The Role of Homocysteine in Dementia Risk Source: https://www.betterbrain.com/articles/the-role-of-homocysteine-in-dementia-risk Description: High homocysteine levels are linked to dementia risk, but B vitamins can reduce levels and slow brain atrophy. The Role of Homocysteine in Dementia RiskAugust 1, 2024Read time:4 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways: B vitamin supplementation can significantly reduce brain atrophy and delay cognitive decline by lowering elevated homocysteine levels.Homocysteine is a naturally occurring amino acid in our body and can spike acutely, such as after staying up all night. In healthy people, homocysteine naturally clears over time. However, at chronic high concentrations, it is associated with various health issues, including heart disease and, notably, cognitive decline. In fact, having blood homocysteine levels over 14 μmol/L is associated with a nearly doubled risk of dementia1. Luckily, there are simple ways to lower your homocysteine levels - most notably B vitamin supplementation. ‍Brain Atrophy, Aging and Cognitive DeclineAs we age, our brains naturally undergo some amount of atrophy, or decrease in size, which involves a loss of neurons and their connections. This process is accelerated in Alzheimer’s dementia2. With a lower brain volume and fewer neural connections, it’s easy to see how atrophy can lead to lasting cognitive impairment. One factor that has a strong influence on the rate of brain atrophy is blood concentration of homocysteine. Several studies3,4 link elevated homocysteine levels are linked with a heightened risk of dementia. ‍The role of B vitaminsYou won’t often hear us say this, but you have an ace up your sleeve in fighting homocysteine: B vitamins. One study2 investigated the effects of using B6, B9, and B12 vitamins over the course of two years, using the same level of rigor that is commonly used for drug clinical trials. On average, people who used B vitamins lowered their overall homocysteine levels by 32% and experienced a 30% slower rate of brain atrophy. In fact, those who started with very high levels of blood homocysteine (> 14 μmol/L) managed to slow their atrophy rate… --- ### Tommy Wood's 3-S Model: The Science Behind Future-Proofing Your Brain Source: https://www.betterbrain.com/articles/tommy-woods-3-s-model-the-science-behind-future-proofing-your-brain Description: BetterBrain's Chief Science Officer Tommy Wood breaks down the three pillars of brain health — Stimulation, Sleep, and Nutrient Supply — and why all three have to work together. Tommy Wood's 3-S Model: The Science Behind Future-Proofing Your BrainJune 2, 2026Read time:5 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:The Framework Behind What We Do at BetterBrainOur Chief Science Officer Tommy Wood published The Stimulated Mind in March 2026, and we think it's the most complete, accessible guide to dementia prevention that exists right now. A rigorous, science-backed model for understanding what your brain actually needs across a lifetime, written by someone who has spent his career studying exactly this.At the center of the book is what Tommy calls the 3-S Model: Stimulation, Support (sleep and recovery), and Supply (of energy and nutrients). These aren't three separate suggestions. They're three categories of input the brain depends on, and Tommy's argument is that they reinforce each other in ways most people don't appreciate. They synergize, providing outsized benefits from even simple changes across all three.BetterBrain is built around exactly this model. The 10 health systems and 11 practices our coaches work through with you are the operational version of what Tommy lays out in the book. Here's a breakdown of each S and one thing you can act on this week.S1: StimulationThe first S is the one that surprises people. Tommy's argument is that the brain, like muscle, needs ongoing challenges to maintain its structure. The variable that matters is novelty. Doing the same crossword every day is not stimulation in the sense your brain cares about. Learning a language, picking up a new instrument, or taking a class on something you have no prior context for, are stimulating.This connects to what researchers call cognitive reserve: the buffer your brain builds through years of varied learning. Cognitive reserve is one of the strongest predictors of who maintains function in their 70s and 80s, even in the presence of pathology like amyloid plaques.What… --- ### Unlocking the Power of Omega-3 Fatty Acids Source: https://www.betterbrain.com/articles/unlocking-the-power-of-omega-3s Description: DHA and EPA, essential omega-3 fatty acids, reduce Alzheimer's risk by supporting brain health and mitigating inflammation. Unlocking the Power of Omega-3 Fatty AcidsSeptember 4, 2024Read time:4 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:Adding DHA and EPA, two essential omega-3 fatty acids found in fatty fish, into your diet can meaningfully reduce the risk of Alzheimer's disease. These fatty acids suppor brain structure, function, and reducing amyloid plaques. As the quest for effective Alzheimer’s prevention continues, recent studies1,2 underscore the profound impact of dietary choices on our brain health. One nutrient class consistently at the forefront of neuroprotective research is Omega-3 fatty acids, particularly Docosahexaenoic Acid (DHA) and Eicosapentaenoic acid (EPA). In this post, we explore how integrating DHA and EPA into your diet can play a crucial role in reducing the risk of Alzheimer's disease.‍Fatty acids explained1DHA and EPA are a major omega-3 fatty acid predominantly found in fish oils. They are called essential fatty acids, meaning that the human body cannot produce them on its own, so they must come from dietary sources. Make sure not to confuse omega-3s (like DHA and EPA) with omega-6s. These are a different class of fatty acids typically found in vegetable oils and nuts. They are much more common in most diets, and can promote inflammation when consumed in excess. DHA and EPA are particularly important because the molecules are building blocks for neurons. This means that maintaining healthy levels of DHA and EPA supports neuronal membrane integrity, promotes healthy synaptic activity, and mitigates inflammation within the brain. Long-term, these fatty acids have been shown to help preserve cognitive abilities and delay the onset of dementia1.‍Clinical insights on Alzheimer’s preventionA growing body of research points to a direct correlation between DHA and EPA intake and a reduction in the risk for Alzheimer's. Animal studies provide compelling evidence, showing that diets rich in DHA can significantly reduce the formation of amyloid plaques, which… --- ### VERVE-102: A One-Time Gene Edit for Cholesterol, and Why It's a Brain Story | BetterBrain Source: https://www.betterbrain.com/articles/verve-102-pcsk9-gene-editing-cholesterol-brain-health Description: VERVE-102: A One-Time Gene Edit for Cholesterol, and Why It's a Brain Story VERVE-102: A One-Time Gene Edit for Cholesterol, and Why It's a Brain Story | BetterBrainJune 16, 2026Read time:5MEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:VERVE-102 is a one-time base-editing therapy that turns down the PCSK9 gene; in the early Heart-2 trial a single infusion lowered LDL by ~50% on average (up to ~69% at higher doses), holding up to 18 months. It mimics a protective pattern that exists in nature: people born with low-functioning PCSK9 have lower lifelong LDL and less heart disease. Big caveats: phase 1b safety trial, small high-risk group (familial hypercholesterolemia / early coronary disease), not general-population data, years from availability. Your lipids are a brain story, not just a heart story. ApoB is the most precise lipid number, and it's testable today.Every so often a piece of research comes along that makes you stop and appreciate how far medicine has come. This is one of those.Researchers just reported early results for a one-time treatment that durably lowers LDL cholesterol by editing a single gene. One infusion, with effects that have held for up to a year and a half so far, and likely to last a lifetime. It's very early research in a small, specific group of patients, and it's years from a doctor's office. But the underlying biology is some of the most well-studied in all of cardiovascular medicine, and it connects directly to your brain.Editing one gene to lower cholesterolThe therapy, called VERVE-102, targets a gene called PCSK9. PCSK9 is a protein that reduces your liver's ability to clear LDL cholesterol from your blood. The more PCSK9 activity you have, the fewer LDL "receptors" your liver keeps available to pull LDL particles out of circulation.Here's the reassuring part: some people are born with naturally low-functioning PCSK9 genes, and they tend to have markedly lower LDL across… --- ### Visceral Fat and the Brain: What 16 Years of Data Actually Show Source: https://www.betterbrain.com/articles/visceral-fat-and-the-brain-what-16-years-of-data-actually-show Description: Visceral Fat and the Brain: What 16 Years of Data Actually Show Visceral Fat and the Brain: What 16 Years of Data Actually ShowMay 12, 2026Read time:5MEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:A 2026 Nature Communications study followed 533 adults for up to 16 years and found that sustained visceral fat loss, not overall weight loss, predicted better cognitive scores and slower brain atrophy. The mechanism appears to be improved glycemic control. Visceral fat drives insulin resistance, which is increasingly understood as a driver of cognitive decline. The biomarkers that respond are HbA1c, fasting insulin, and metabolic panels. They shift before the scale does and tell you whether the metabolic conditions for visceral fat accumulation are changing.A study just landed in Nature Communications that reframes how to think about midlife weight loss and brain health. Researchers followed 533 adults for up to 16 years after they completed lifestyle interventions, then scanned their brains and tested their cognition. The finding: it wasn't weight loss that predicted slower brain atrophy and better cognitive scores years later. It was sustained loss of visceral fat specifically.‍This matters because most people, and most doctors, still track weight on a scale. The number on the scale lumps together fat, muscle, water, and where on the body the fat actually sits. The new data suggests that for brain health, where the fat is matters more than how much of it there is.‍What the study found‍The research, called the Follow-Interventions-Trials (FIT) project, pulled participants from four earlier 18 to 24 month lifestyle randomized trials. The average age at follow-up was 61. Each participant had abdominal MRI, brain MRI, and Montreal Cognitive Assessment (MoCA) testing 5 to 16 years after their original intervention.‍Three findings stood out. Lower long-term visceral fat exposure, calculated across baseline, post-intervention, and follow-up, independently predicted higher cognitive scores. Visceral fat loss during the intervention period predicted higher brain… --- ### Why Is Alzheimer's More Common in Women? Source: https://www.betterbrain.com/articles/why-alzheimers-affects-women-more Description: Alzheimer's impacts more women, not just due to longevity. Menopause and hormonal changes play key roles in the higher prevalence among women. Why Is Alzheimer's More Common in Women?July 7, 2023Read time:4 minsMEDICALLY REVIEWED BYCourtney Giles, BSN RNBetterBrain Health CoachKey takeaways:When it comes to Alzheimer's disease, gender plays an undeniable role. A staggering two-thirds of those diagnosed with Alzheimer's in the United States are women. This disparity has puzzled researchers for years. Initially, many attributed it to the longer lifespan of women compared to men. However, as our understanding of the disease deepens, we've learned that longevity alone doesn't fully explain the 2X difference in prevalence.‍The Longevity Theory Falls ShortFor a long time, the prevailing explanation for why more women than men were diagnosed with Alzheimer's was simple: women live longer, and Alzheimer's is a disease that primarily affects older adults. However, this explanation has increasingly come under scrutiny. As it turns out, the difference in lifespan between men and women isn't sufficient to account for the wide gap in Alzheimer's cases. The narrative is much more nuanced and involves a complex interplay of biological and social factors.‍The Menopause Transition HypothesisMenopause is a significant biological milestone in a woman's life, marked by the end of menstrual cycles and fertile years. One of the most significant changes that accompany menopause is a decline in estrogen levels. Estrogen is not just a reproductive hormone; it also has protective effects on the brain. The sharp decrease in estrogen during the menopause transition has been hypothesized to elevate the risk of Alzheimer's among women. In fact, cognitive decline associated with reduced estrogen levels has been reported, especially during the peri-menopausal and post-menopausal phases.A beacon of hope: Hormone Replacement Therapy (HRT)Given the hypothesized link between menopause and Alzheimer's risk, Hormone Replacement Therapy (HRT) has been studied as a potential preventive measure. Some evidence indicates that HRT could mitigate the risk of Alzheimer's among post-menopausal women. One prospective study1in particular demonstrated… --- ## Pages ### Take control of your brain health Source: https://www.betterbrain.com Description: BetterBrain provides personalized brain check-ups and expert coaching to help you prevent Dementia & Alzheimer's disease. Start your brain health journey today! Join 22,460+ People Optimizing Brain HealthTake control of your brain healthThink sharper today. Prevent dementia tomorrow. A no-cost, science-backed system for better brain health, with coaching often $0 with insurance.See your optionsCoaching often covered by employer sponsored insuranceMedicare coverage coming soonNearly 1 in 2 dementia cases‍ can be preventedA 2024 Lancet Commission report determined that 45% of dementia cases are potentially preventable by addressing modifiable risk factors.Apolipoprotein BFerritinProcessing SpeedOmega 3TriglyceridesMonocytesHomocysteineInsulinUric acidVitamin B12Apolipoprotein BFerritinProcessing SpeedOmega 3TriglyceridesMonocytesHomocysteineInsulinUric acidVitamin B12TSHLipoprotein (a)FolateGut healthRDWEnergyMoodPhysical functionpTau-217HSV-1 / HSV-2ToxinsProcessing SpeedTSHLipoprotein (a)FolateGut healthRDWEnergyMoodPhysical functionpTau-217HSV-1 / HSV-2ToxinsProcessing SpeedFolateMCVLipoprotein (a)Vitamin DAPOE geneticsPhysical functionTSHExecutive FunctionOmega 3hs-CRPFolateMCVLipoprotein (a)Vitamin DAPOE geneticsPhysical functionTSHExecutive FunctionOmega 3hs-CRPEnergyToxinsTriglycerideshs-CRPInsulinMemoryGut healthExecutive FunctionMoodFerritinEnergyToxinsTriglycerideshs-CRPInsulinMemoryGut healthExecutive FunctionMoodFerritin How BetterBrain empowers youPerformanceEnhance processing speed, memory, and focus. Target the root-causes of brain fog and mental fatiguePreventionReduce the risk of dementia and protect your brain from decline.Lifelong Well-BeingEnjoyment, meaning, and independence your whole lifeHow it worksStep 1UnderstandTest what matters for your brain across 10 body systems in a single dashboard.Step 2PlanGet a personalized action plan ranked by impact, matched to your biology and budget.Step 3ActHuman coaches plus 24/7 AI to keep you on track. Vetted products curated for you.Step 1UnderstandTest what matters for your brain across 10 body systems in a single dashboard.Step 2PlanGet a personalized action plan ranked by impact, matched to your biology and budget.Step 3ActHuman coaches plus 24/7 AI to keep you on track. Vetted products curated for you.The science behind BetterBrain Emerging brain science offers more good news than most realizeFactYou can dramatically improve your brain healthScience now shows that through a personalized set of interventions, you can immediately improve your cognitive performance and significantly reduce your risk of dementia.Learn more about the scienceFactBetterBrain is grounded in the science of The Stimulated MindWritten by our Chief Science Officer, Dr. Tommy Wood. Every client receives two copies: one to keep, and… --- ### Questions? We're here to help - BetterBrain Source: https://www.betterbrain.com/contact Description: Betterbrain: Start your brain health journey today! We're here to answer your questions and support you. Questions? We're here to helpWe will respond as soon as possibleNameEmailMessageThank you! Your submission has been received!Oops! Something went wrong while submitting the form. --- ### GreyMatters Source: https://www.betterbrain.com/greymatters Description: Educational articles, BetterBrain resources, latest in brain health, and news about us. Written for you, with expertise (and love). Latest articlesScienceHacksNewsResearchThank you! Your submission has been received!Oops! Something went wrong while submitting the form.ResearchJune 16, 20265VERVE-102: A One-Time Gene Edit for Cholesterol, and Why It's a Brain Story | BetterBrainPost summary: A single-dose gene editing therapy just posted striking early results for lowering LDL cholesterol. Here's how it works, the honest caveEvery so often a piece of research comes along that makes you stop and appreciate how far medicine has come. This is one of those.Researchers just reported early results for a one-time treatment that durably lowers LDL cholesterol by editing a single gene. One infusion, with effects that have held for up to a year and a half so far, and likely to last a lifetime. It's very early research in a small, specific group of patients, and it's years from a doctor's office. But the underlying biology is some of the most well-studied in all of cardiovascular medicine, and it connects directly to your brain.Editing one gene to lower cholesterolThe therapy, called VERVE-102, targets a gene called PCSK9. PCSK9 is a protein that reduces your liver's ability to clear LDL cholesterol from your blood. The more PCSK9 activity you have, the fewer LDL "receptors" your liver keeps available to pull LDL particles out of circulation.Here's the reassuring part: some people are born with naturally low-functioning PCSK9 genes, and they tend to have markedly lower LDL across their entire lives, substantially lower rates of heart disease, and no apparent downside. Turning down PCSK9 is a protective pattern scientists have studied for two decades. We already have approved PCSK9-lowering drugs; they just require ongoing injections.What's new is the delivery. VERVE-102 uses base editing, a precise form of gene editing, to make a single change to the PCSK9 gene in liver cells after one infusion, doing once, durably, what current… --- ### The science behind BetterBrain Source: https://www.betterbrain.com/science Description: The science behind BetterBrain. Emerging brain science offers more good news than most realize The science behind BetterBrainEmerging brain science offers more good news than most realizeFactYou can dramatically improve your brain health.There is no magic pill for brain health (yet) - but science has shown that through a personalized set of interventions, you can dramatically reduce your risk of dementia while immediately improving your cognitive function. Nearly 1 in 2 dementia cases‍ can be preventedA 2024 Lancet Commission report determined that 45% of dementia cases are potentially preventable by addressing modifiable risk factors.Why haven't Iheard this before?In short, the medical system lags behind cutting edge scienceOver 50% of studies related to "dementia prevention" have been published in the last 5 yearsMedical guidelines and clinical practice typically lag 10+ years behind new scientific research, even after a consensus is reachedThe first Alzheimer's Prevention Clinic was opened in 2013There are now ~6 such clinics in the US, but waitlists often reach 5+ yearsNumber of publications on PubMed for keywords "dementia prevention" over the last 25 yearsExplore the science using the links belowBetterBrain's promise is based in the findings from hundreds of scientific studies published in top tier journals. Some studies explore brain health holistically while others are targeted to specific risks factors or interventions.Holistic StudiesResearch investigating a broad range of interventionsNew studyTowards a future where Alzheimer’s disease pathology is stopped before the onset of dementiaNature mental health-May 2024New studyDementia prevention in clinical practiceSeminars in Neurology-Nov 2022New studyFINGER: A randomised controlled trialThe Lancet-Mar 2015New studyDementia prevention, intervention, and careThe Lancet-Jul 2020New studyDementia prevention, intervention, and care: 2024 report of the Lancet standing CommissionThe Lancet-Jul 2024New studyAlzheimer’s disease risk reduction in clinical practiceNature mental health-Jan 2024Targeted StudiesResearch analyzing a specific domain that influences brain healthPLoS Medicine-May 2017Cognitive reserveBritish Journal of Psychiatry-Jan 2018Mental healthJournal of Alzheimer's Disease-May 2022Immune healthNational Institute on Aging-Jun 2023Gut healthBMJ-Sep 2004ToxinsAlzheimer's Research & Therapy-Jan… --- ### Choose your brain health program Source: https://www.betterbrain.com/pricing-old Lingering questions?Book a free 15-minute consultation to learn more and get tipsSchedule nowStart your journey todayNot ready for a full program? Create a free account to access brain health research, expert insights, and science-backed content.Create a free accountFree BetterBrain AccountCutting-edge research insightsAd-free contentExpert Q&A accessValidated products Why our clients‍love us"Within  3 months, I was able to completely change my bloodwork"KimBetterBrain member since 2023“BetterBrain helped me cut through the noise and focus on what actually works.”AmyBetterBrain member since 2023“BetterBrain exceeded our expectations—4X the information we were looking for. It changed so much in my life.”CaraBetterBrain member since 2023"BetterBrain made it so easy to assess my risk & formulate a plan"AnaBetterBrain member since 2023“Incredible value. Unique access to cutting-edge science for your brain health.”VictoriaBetterBrain member since 2023“I finally have a sense of control and stopped feeling hopeless about my brain health.”SandraBetterBrain member since 2023"They had the answer to every crazy question I had and the science to back it up"AmyBetterBrain member since 2023 --- ### Privacy Policy Source: https://www.betterbrain.com/privacy-policy Description: Learn how BetterBrain Health collects, uses, and protects your personal information. Review our privacy practices, data security measures, and your rights. Privacy PolicyLast updated May, 2026This Privacy Policy (“Privacy Policy”) describes how BetterBrain Health, Inc. (“BetterBrain,” “we,” “our,” or “us”) and our affiliates, subsidiaries, and other related entities (collectively, “Related Entities”) and contracted professional entities collect, use, share, and protect personal information when you access or use our websites, applications, services, and related offerings (collectively, the “Services”). Please read it carefully to understand how we collect, use, and protect your information.BetterBrain operates the BetterBrain platform and manages non-clinical and administrative aspects of the Services, including technology, analytics, and customer experience. Certain health, wellness or diagnostic services available through the Services are provided by licensed professionals affiliated with Affiliated Providers — healthcare providers, medical groups, labs, and other clinical partners with which BetterBrain contracts to make clinical services available through the platform. 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This Privacy Policy is binding on all those who access or use the Services, whether acting as an individual or on behalf of an entity, including you and all persons, entities, or digital engines of any kind that harvest, crawl, index, scrape, spider, or mine digital content by an automated or… --- ### Terms & conditions Source: https://www.betterbrain.com/terms Terms & conditionsLast updated: May 2026‍AGREEMENT TO OUR LEGAL TERMSThese terms (the "Legal Terms" or “Terms”) govern your use of the BetterBrain Health, Inc. website, located at https://betterbrain.com/ (the “BetterBrain Website”), as well as any other related products and services that refer or link to these legal terms (collectively, the "Platform").As part of offering the Services, BetterBrain works with affiliated healthcare providers, medical groups, labs, and other clinical partners with which BetterBrain may contract to make clinical services available through the platform (collectively, “Affiliated Providers”). Our Services include access to professional healthcare services provided by Affiliated Providers, and your access to and use of these Services is subject to these Terms.Throughout these Terms “BetterBrain”, “we”, “us”, and “our” means and refers to BetterBrain Health, Inc. and its current and future formed subsidiaries and affiliates. “You”, “your” means and refers to the person using the Services.Please read the Legal Terms carefully before accessing or using the Services as it sets forth important information that you as a user (“You") need to understand about the Services. These Legal Terms constitute a legally binding agreement made between You, whether personally or on behalf of an entity as a user of the Services, and BetterBrain Health, Inc., concerning Your access to and use of the Services. You agree that by accessing, browsing, otherwise using the Services, You have read, understood, and agreed to be bound by all of these Legal Terms. IF YOU DO NOT AGREE WITH THE LEGAL TERMS, THEN YOU MAY DISCONTINUE USE OF THE SERVICES IMMEDIATELY. YOU AGREE THAT THE AGREEMENT FORMED BY THESE LEGAL TERMS IS LIKE ANY WRITTEN, NEGOTIATED AGREEMENT SIGNED BY YOU, AND YOU AGREE TO BE BOUND BY, AND FULLY COMPLY WITH, ITS TERMS. YOU REPRESENT AND WARRANT THAT YOU HAVE ALL NECESSARY RIGHTS, POWER, AND AUTHORITY TO… --- ### consultation Source: https://www.betterbrain.com/consultation Description: Schedule a consultation with BetterBrain to learn about pTau-217 testing and brain health assessment. Start your journey to better cognitive wellness today. --- ### pTau-217 Source: https://www.betterbrain.com/ptau217 pTau-217The blood test reshaping Alzheimer's scienceGet pTau-217 testHow might pTau-217 fit into my dementia prevention journey?Alzheimer’s disease starts up to 20 years before symptoms appearWithout early detection, the first sign of trouble is usually cognitive decline, which can rapidly progress to Alzheimer's DementiaHere's the good news:pTau-217 testing can identify the disease 20 years before symptomsThere are many things you can do to slow or stop the progressionHow might pTau-217 fit into my dementia prevention journey?Example journeyAlzheimer’s disease starts up to 20 years before symptoms appearWithout early detection, the first sign of trouble is usually cognitive decline, which can rapidly progress to Alzheimer's DementiaHere's the good news:pTau-217 testing can identify the disease 20 years before symptomsThere are many things you can do to slow or stop the progressionExample journey1No disease2Preclinical Alzheimer's - limited to no cognitive symptoms3Mild Cognitive Impairment4Alzheimer's dementiaWhy should I consider pTau-217 testing?Get peace of mind: Rest easy knowing you won’t get blindsided by the diseaseDetect the disease up to 20 years before symptoms start so that you have plenty of time to act to slow or stop the progressionGet a direct measure of Alzheimer’s pathology to help understand the impact of your prevention effortsHelp determine your eligibility for Leqembi and/or Kinsula, which evidence suggests are more effective when used earlierSee how leading neurologists are using pTau-217 for Alzheimer’s preventioncnn.comWho should get pTau-217?We believe that pTau-217 can be a highly valuable test for anyone over 45 who wants to be proactive about their brain health. However, getting tested is a very personal choice.Some professionals believe that only patients with cognitive symptoms should take this test since there is no drug for prevention. Others (including us) believe this overlooks the significant evidence non-drug interventions can dramatically delay or prevent the disease.Two important considerationsTest limitations: Scientists are still working out exactly what… --- ### Consultation-Wendy Source: https://www.betterbrain.com/consultation/wendy-p/wp75 Description: Schedule your personalized brain health consultation with Wendy P. Join BetterBrain's pTau-217 testing program and take control of your cognitive wellness. --- ### Consultation-Uma Source: https://www.betterbrain.com/consultation/uma-p/up60 Description: Schedule your personalized brain health consultation with Uma. Get expert guidance on cognitive wellness and pTau-217 testing at BetterBrain. --- ### Consultation-Wendy-15m Source: https://www.betterbrain.com/consultation/wendy-p/wp15 --- ### Prevent dementia.Think & feel better. Source: https://www.betterbrain.com/employers Description: BetterBrain provides personalized brain check-ups and expert coaching to help you prevent Dementia & Alzheimer's disease. Start your brain health journey today! Help Defeat Dementia, Starting with YourselfWe’re inviting a small group of business leaders to help democratize access to life-changing brain health science and spark a virtuous cycle of innovation.‍To get started, we’d love for you—and a loved one—to experience BetterBrain at no cost. If you find it valuable, we hope you’ll help bring it to others in your company and network.‍Get BetterBrain at No CostThe BackstoryWe started BetterBrain 18 months ago with top clinicians and business leaders. Tom led the McKinsey Health Institute and its AI and healthcare practices. Cedric brings deep experience in digital health, employee benefits, and worked with Dr. Peter Attia.Brain health is personal. Tom’s mother-in-law died from Alzheimer’s after years of bad guidance. Cedric learned he—and several loved ones—carry elevated dementia risk and began studying prevention.The good news: Research shows we can boost brain performance and cut dementia risk. At least 45% of cases are preventable—and most can be delayed.The bad news: Fewer than 5% of doctors know this science. Insurance ignores prevention. Elite programs exist—but cost $3K–$5K+, take days, and have long waits.We built something better.BetterBrain is a first-of-its-kind virtual brain health platform. It’s rigorous, evidence-based, and 1/10 the cost. It combines diagnostics, expert guidance, and personalized plans to improve how people think and feel—while cutting long-term dementia risk.Thousands have used it. Results are strong—better thinking, better mood, deep appreciation. Now, we’re inviting a small group of leaders to try it—and help expand access.We're offering you and a loved one a free experience (normally $399 each). In return, we ask:1. A short chat or email with your feedback.2. If it resonates, a warm intro to someone on your HR or benefits team.No pressure—if it’s not a fit, we still hope you’ll try it.And to be clear: your data is 100% private. Nothing is shared without… --- ### Consultation-Stacy Source: https://www.betterbrain.com/consultation/stacy-d/sd60 Description: Schedule your personalized brain health consultation with Stacy D. Get expert guidance on pTau-217 testing and cognitive wellness strategies. --- ### Emily-75 Source: https://www.betterbrain.com/consultation/emily-c/ec75 Description: Access your personalized brain health consultation with Emily. Review your pTau-217 results and next steps for cognitive wellness. --- ### Emily-15 Source: https://www.betterbrain.com/consultation/emily-c/ec15 Description: Access your personalized BetterBrain consultation session. Review your pTau-217 results and brain health insights with expert guidance. --- ### BetterBrain makes brain health accessible to all Source: https://www.betterbrain.com/about-us Description: Meet the team behind BetterBrain. We're on a mission to empower every person to take charge of their brain health and make dementia an orphan disease. BetterBrain makes brain health accessible to allWe're all about livingWe believe everyone on Earth deserves the opportunity to lead a life filled with meaning, intimacy, adventure, and enjoyment.‍Leading a full life your whole life requires a healthy brain.Yet somehow, the brain is the organ most neglected by our healthcare systems. Inspired by inadequate experiences in our own families, we started BetterBrain to change that.Who we areWe are a multidisciplinary group of people who want to help others improve their brain health and prevent dementia.We partner with other individuals and groups who believe in our goal to build a community that can support, empower, and learn from itself.See our clinical and operational teamWhy we built BetterBrainDementia has touched all of our families. We’ve seen first hand the impact dementia has and the standard of care our loved ones received. It made us angry.We're a team of nerds who love to read science, and the science shows there are solutions that can help significantly improve peoples' lives.We built BetterBrain to make them available to everyone.Learn more from our co-foundersWho we areWe are a multidisciplinary group of people who want to help others improve their brain health and prevent dementia.We partner with other individuals and groups who believe in our goal to build a community that can support, empower, and learn from itself.See our clinical and operational team Why we built BetterBrainDementia has touched all of our families. We’ve seen first hand the impact dementia has and the standard of care our loved ones received.It made us angry.We're a team of nerds who love to read science, and the science shows there are solutions that can help significantly improve peoples' lives. We built BetterBrain to make them available to everyone.Learn more from our co-founders "I co-founded BetterBrain to honor my late mother-in-law, Becky… --- ### Rewind the clock Source: https://www.betterbrain.com/how-it-works Description: Worried about Dementia? BetterBrain offers at-home brain check-ups, personalized protocols & expert support to protect your brain health. Contact us! Rewind the clockWhat if you had the dementia risk and mental sharpness of someone 10-20 years younger?BetterBrain in practiceInsightsGet a comprehensive and convenient brain check-up ImproveAct on your results using a tailored protocol and expert guidanceYour BetterBrain journeyBrain health in today's healthcare system is full of outdated practices, long lines, and unnecessary complexity.BetterBrain complements your existing clinical care and makes the cutting edge simple and accessible.Step 1Establish a baselineStart by completing your health questionnaire and cognitive test. Get your blood draw from a local lab, or have a licensed phlebotomist come to your home (where available).Understand and planVisualize your results and see your top opportunities in plain English. Create a personalized protocol that fits your biology, constraints, and lifestyle. Step 2Act on your planPut your plan into practice and let us help you stay on track. Access curated products and more advanced clinical services if needed.Step 3Retest and adaptRetest your most critical markers after 3 months to see your progress and adapt your plan accordingly.Step 4 BetterBrain’s approach to brain healthAchieving brain health requires a deep, holistic understanding of your health and using evidence based practices to improve your well-being and reduce risk.InsightsBrain health and dementia risk are best understood using four complementary lenses.Each lens helps identify risks, prioritize actions to take, and track whether those actions are working.ImproveBrain function & dementia risk can be substantially improved using 5 principles, which are divided into 11 practices.They are especially powerful when used together and are tailored to specific risk factors.Brain physiology Brain specific-markers including amyloid and tau levels, blood flow,  neurotransmitter activity, brain volume, and signs of damage.Whole-body health A biomarker-based understanding of the 10 bodily systems that most impact dementia risk and well-beingCognitive performance An objective understanding of how well you currently think, remember, and solve problemsDaily function Your mood, clarity,… --- ### The first dementia prevention program covered by insurance Source: https://www.betterbrain.com/insurance Description: BetterBrain provides personalized brain check-ups and expert coaching to help you prevent Dementia & Alzheimer's disease. Start your brain health journey today! 92% of our clients pay $0 per sessionThe first dementia prevention program covered by insuranceA science-based 12-week program including weekly expert coaching and optional comprehensive testing to help reduce dementia risk, think better, and feel better.Am I covered?Coaching often covered by employer sponsored insuranceMedicare coverage coming soonAs featured in Faster, cheaper, better: the rise of blood tests for Alzheimer’sNearly 1 in 2 dementia cases‍ can be preventedA 2024 Lancet Commission report determined that 45% of dementia cases are potentially preventable by addressing modifiable risk factors.Apolipoprotein BFerritinProcessing SpeedOmega 3TriglyceridesMonocytesHomocysteineInsulinUric acidVitamin B12Apolipoprotein BFerritinProcessing SpeedOmega 3TriglyceridesMonocytesHomocysteineInsulinUric acidVitamin B12TSHLipoprotein (a)FolateGut healthRDWEnergyMoodPhysical functionpTau-217HSV-1 / HSV-2ToxinsProcessing SpeedTSHLipoprotein (a)FolateGut healthRDWEnergyMoodPhysical functionpTau-217HSV-1 / HSV-2ToxinsProcessing SpeedFolateMCVLipoprotein (a)Vitamin DAPOE geneticsPhysical functionTSHExecutive FunctionOmega 3hs-CRPFolateMCVLipoprotein (a)Vitamin DAPOE geneticsPhysical functionTSHExecutive FunctionOmega 3hs-CRPEnergyToxinsTriglycerideshs-CRPInsulinMemoryGut healthExecutive FunctionMoodFerritinEnergyToxinsTriglycerideshs-CRPInsulinMemoryGut healthExecutive FunctionMoodFerritin How BetterBrain empowers youPerformanceEnhance processing speed, memory, and focus. Target the root-causes of brain fog and mental fatiguePreventionReduce the risk of dementia and protect your brain from decline.Lifelong Well-BeingEnjoyment, meaning, and independence your whole lifeHow it worksStep 1UnderstandTest what matters for your brain across 10 body systems in a single dashboard.Step 2PlanGet a personalized action plan ranked by impact, matched to your biology and budget.Step 3ActHuman coaches plus 24/7 AI to keep you on track. Vetted products curated for you.Step 1UnderstandTest what matters for your brain across 10 body systems in a single dashboard.Step 2PlanGet a personalized action plan ranked by impact, matched to your biology and budget.Step 3ActHuman coaches plus 24/7 AI to keep you on track. Vetted products curated for you. BetterBrain's clinical advisorsBetterBrain is continually evolving with expert-led, science-driven insightsTommy Wood, MD, PhDCraig Tanio, MD, FACPJay Saenz, MDBen Rein, PhDNow introducing pTau-217A groundbreaking new blood test to detect Alzheimer's up to 20 years in advance so you can take action to slow or stop its progression.Blood Biomarkers to Detect Alzheimer Disease in Primary Care… --- ### Know your risks stay sharp Source: https://www.betterbrain.com/untitled Nearly 1 in 2 dementia cases‍ can be preventedA 2024 Lancet Commission report determined that 45% of dementia cases are potentially preventable by addressing modifiable risk factors.4Apolipoprotein BFerritinProcessing SpeedOmega 3TriglyceridesMonocytesHomocysteineInsulinUric acidVitamin B12Apolipoprotein BFerritinProcessing SpeedOmega 3TriglyceridesMonocytesHomocysteineInsulinUric acidVitamin B12TSHLipoprotein (a)FolateGut healthRDWEnergyMoodPhysical functionpTau-21HSV-1 / HSV-2ToxinsProcessing SpeedTSHLipoprotein (a)FolateGut healthRDWEnergyMoodPhysical functionpTau-21HSV-1 / HSV-2ToxinsProcessing SpeedFolateMCVLipoprotein (a)Vitamin DAPOE geneticsPhysical functionTSHExecutive FunctionOmega 3hs-CRPFolateMCVLipoprotein (a)Vitamin DAPOE geneticsPhysical functionTSHExecutive FunctionOmega 3hs-CRPEnergyToxinsTriglycerideshs-CRPInsulinMemoryGut healthExecutive FunctionMoodFerritinEnergyToxinsTriglycerideshs-CRPInsulinMemoryGut healthExecutive FunctionMoodFerritin How BetterBrain empowers youfeature-cards_bg-imageWe will identify and address your unique risks to maintain lifelong brain health.Improve mental sharpnessAccess the same science-backed approaches used in leading dementia prevention clinicsFeel better todayEnjoy the whole body health improvements that come with a comprehensive brain health program.Now introducing pTau-217A groundbreaking new blood test to detect Alzheimer's up to 20 years in advance so you can take action to slow or stop its progression.Learn MoreFaster, cheaper, better: the rise of blood tests for Alzheimer’sBlood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary CareA Blood Test Accurately Diagnosed Alzheimer’s 90% of the Time, Study FindsSigns of Alzheimer’s were everywhere - then his brain improvedBiomarker Changes during 20 Years Preceding Alzheimer’s DiseaseAlzheimer's Biomarkers Show Tantalizing Hint at Utility for Tracking PreventionHighly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid testsBetterBrain's clinical advisorsBetterBrain is continually evolving with expert-led, science-driven insightsFind the plan that's‍ right for youWhy our clientslove usUnsure where to start?Join BetterBrain at no costJoin at no cost --- ### Detect dementia early, start your prevention journey Source: https://www.betterbrain.com/ptau Description: BetterBrain provides personalized brain check-ups and expert coaching to help you prevent Dementia & Alzheimer's disease. Start your brain health journey today! Join 22,460+ People Optimizing Brain HealthDetect dementia early, start your prevention journeyGet a head start on the disease and take steps to prevent and delay symptoms.Simple at-home pTau-217 blood testDetect dementia up to 20 years before symptoms startActionable, science-backed prevention programGet tested todayAs featured in Faster, cheaper, better: the rise of blood tests for Alzheimer’sAs featured in Faster, cheaper, better: the rise of blood tests for Alzheimer’spTau-217 The future of early dementia detection is here Elevated blood levels of Ptau variants 181 and 217 are among the earliest warning signs of Alzheimer's—and are directly linked to the buildup of amyloid plaques in the brain. Ptau levels begin to rise as the brain starts accumulating amyloid plaques, often appearing up to 20 years before symptoms begin.Measuring Ptau provides a safe, simple way to detect amyloid plaque early —without the need for invasive procedures like PET scans or spinal taps. With a simple blood test, you can take control early—giving yourself more time to act, slow disease progression, and explore preventative programs.Get tested todayUnderstand your risk, change your trajectory.47 millionAmericans have pre-clinical Alzheimer's (most don't know it)20-30 yearsAlzheimer's disease starts 20-30 years before symptoms beginNearly 1 in 2Cases can be prevented through early intervention, and the rest can be delayedHow it works:Get tested, get informed, get ahead1.Order your blood testSchedule a blood draw from 1 of our 2,000 partner labs, or choose an at-home blood draw for extra comfort.2.Receive Your ResultsYour results will be available within 5 days and will be personally explained to you by a dementia specialist who will help you understand the results & implications.3.Begin Your Prevention JourneyUncovering high pTau levels doesn't mean you're powerless. Join BetterBrain's prevention program to take back control and reduce your overall risk.Get startedHigh Ptau Levels detected? Nearly 1 in 2 dementia cases‍ can… --- ### Choose your brain health program Source: https://www.betterbrain.com/pricing Lingering questions?Book a free 15-minute consultation to learn more and get tipsSchedule nowStart your journey todayNot ready for a full program? Create a free account to access brain health research, expert insights, and science-backed content.Create a free accountFree BetterBrain AccountCutting-edge research insightsAd-free contentExpert Q&A accessValidated products Why our clients‍love us"Within  3 months, I was able to completely change my bloodwork"KimBetterBrain member since 2023“BetterBrain helped me cut through the noise and focus on what actually works.”AmyBetterBrain member since 2023“BetterBrain exceeded our expectations—4X the information we were looking for. It changed so much in my life.”CaraBetterBrain member since 2023"BetterBrain made it so easy to assess my risk & formulate a plan"AnaBetterBrain member since 2023“Incredible value. Unique access to cutting-edge science for your brain health.”VictoriaBetterBrain member since 2023“I finally have a sense of control and stopped feeling hopeless about my brain health.”SandraBetterBrain member since 2023"They had the answer to every crazy question I had and the science to back it up"AmyBetterBrain member since 2023 --- ### Sarah Source: https://www.betterbrain.com/consultation/sarah Description: Schedule your personalized brain health consultation with Sarah. Get expert guidance on pTau-217 testing and cognitive wellness strategies. --- ### Take control of your brain health Source: https://www.betterbrain.com/home-quiz Description: BetterBrain provides personalized brain check-ups and expert coaching to help you prevent Dementia & Alzheimer's disease. Start your brain health journey today! Join 22,460+ People Optimizing Brain HealthTake control of your brain healthExpert-backed brain health assessments and guidance to reduce your risks, think better, and feel betterStart quizAs featured in Faster, cheaper, better: the rise of blood tests for Alzheimer’sAs featured in Faster, cheaper, better: the rise of blood tests for Alzheimer’sNearly 1 in 2 dementia cases‍ can be preventedA 2024 Lancet Commission report determined that 45% of dementia cases are potentially preventable by addressing modifiable risk factors.Apolipoprotein BFerritinProcessing SpeedOmega 3TriglyceridesMonocytesHomocysteineInsulinUric acidVitamin B12Apolipoprotein BFerritinProcessing SpeedOmega 3TriglyceridesMonocytesHomocysteineInsulinUric acidVitamin B12TSHLipoprotein (a)FolateGut healthRDWEnergyMoodPhysical functionpTau-217HSV-1 / HSV-2ToxinsProcessing SpeedTSHLipoprotein (a)FolateGut healthRDWEnergyMoodPhysical functionpTau-217HSV-1 / HSV-2ToxinsProcessing SpeedFolateMCVLipoprotein (a)Vitamin DAPOE geneticsPhysical functionTSHExecutive FunctionOmega 3hs-CRPFolateMCVLipoprotein (a)Vitamin DAPOE geneticsPhysical functionTSHExecutive FunctionOmega 3hs-CRPEnergyToxinsTriglycerideshs-CRPInsulinMemoryGut healthExecutive FunctionMoodFerritinEnergyToxinsTriglycerideshs-CRPInsulinMemoryGut healthExecutive FunctionMoodFerritin How BetterBrain empowers youReduce your risksWe will identify and address your unique risks to maintain lifelong brain health.Improve mental sharpnessAccess the same science-backed approaches used in leading dementia prevention clinicsFeel better todayEnjoy the whole body health improvements that come with a comprehensive brain health program.Now introducing pTau-217A groundbreaking new blood test to detect Alzheimer's up to 20 years in advance so you can take action to slow or stop its progression.Learn MoreBlood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary CareA Blood Test Accurately Diagnosed Alzheimer’s 90% of the Time, Study FindsSigns of Alzheimer’s were everywhere - then his brain improved No items found.Faster, cheaper, better: the rise of blood tests for Alzheimer’sBlood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary CareA Blood Test Accurately Diagnosed Alzheimer’s 90% of the Time, Study FindsSigns of Alzheimer’s were everywhere - then his brain improvedBiomarker Changes during 20 Years Preceding Alzheimer’s DiseaseAlzheimer's Biomarkers Show Tantalizing Hint at Utility for Tracking PreventionHighly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid tests BetterBrain's clinical advisorsBetterBrain is continually evolving with expert-led, science-driven… --- ### Year 2: Building on your progress‍ Source: https://www.betterbrain.com/pricing-renewal --- ### Consent to Treat Source: https://www.betterbrain.com/consent-for-services Description: Review and understand BetterBrain Health's consent to treat form, including telehealth services, privacy policies, and patient rights for medical care. Consent to TreatLast updated November 12, 2025I hereby give my informed consent for medical treatment and procedures to be administered by the healthcare professionals at Cloud Health Medical Group, P.A., Cloud Health Medical Group of California, P.C., Cloud Health Medical Group of New Jersey, P.A. Cloud Health Medical Group of Kansas, P.C., Cognitive Nutrition & Wellness LLC and Pesto Health, Inc. (collectively “Providers”).I understand and acknowledge the following:Nature of Consent:I understand that by signing this form, I am authorizing Providers and its healthcare providers to provide medical evaluations, conduct diagnostic tests, and perform necessary procedures to diagnose and treat my medical condition.Telehealth:Telehealth services involve interactive video conferencing equipment and devices that let your health care provider deliver health care services to you from a location that is different than your location. I confirm that I have read this form (or had it explained to me) and understand the following:I will not be physically in the same room as my health care provider during the visit. I will be told about and asked for my consent before any other Providers staff or trainees actively assist my health care provider during this visit.There are risks and consequences associated with telehealth services. These include, but are not limited to:disruption of the appointment caused by technology failures;the limited ability of my health care provider to respond to emergencies during the visit;interruption or violations of confidentiality by people who do not have permission to be at the visit. While Providers takes all reasonable steps to secure telehealth visits and breaches are very rare, no technology is completely secure; andthe chance that I or my health care provider decides that the video conferencing equipment or connection is not adequate for this visit and decides to stop the telemedicine visit, switch to an alternate Providers-approved video conferencing… --- ### HIPAA Authorization Source: https://www.betterbrain.com/hipaa-authorization Description: Review and understand BetterBrain's HIPAA Authorization for protected health information disclosure through Vital's API services for at-home healthcare. HIPAA AuthorizationLast updated November 12, 2025Adept Labs, Inc. d/b/a Vital (“Vital”) provides API solutions for at-home health care. Vital contracts with enterprise customers to grant access to Vital’s services to the customers’ patients like you. As part of its service, Vital works with health care providers and lab testing facilities to facilitate sharing your protected health information as governed by the Health Insurance Portability and Accountability Act of 1996 (“HIPAA”), 42 U.S.C. § 1320d and 45 C.F.R. § 160–164.This HIPAA Authorization is to authorize the disclosure of your information from Vital to BetterBrain Health, Inc., and its affiliates Cognitive Nutrition & Wellness LLC and Pesto Health, Inc. (together, “BetterBrain”), our enterprise customer. By signing below, you agree as follows:Pursuant to HIPAA, I authorize and direct Vital to give, disclose, and release, without restriction, my medical records, lab order, and/or lab testing results to BetterBrain.The purpose of the uses and disclosures is for care coordination.I understand that, with certain exceptions, I have the right to revoke this Authorization at any time. If I want to revoke this Authorization, I must do so in writing. I may revoke this Authorization by sending an email to support@tryvital.io stating my desire to revoke my HIPAA Authorization. I understand that it may take Vital a few business days to process my revocation.I understand that I may refuse to sign this Authorization, but that will prevent me from participating in Vital’s services. I also understand that my health care provider cannot deny or refuse to provide treatment, payment, enrollment in a health plan, or eligibility of benefits if I refuse to sign this Authorization.I understand that, once information is disclosed pursuant to this Authorization, it is possible that it will no longer be protected by applicable federal medical privacy law and could be re-disclosed by the… --- ### Notice of Privacy Practices Source: https://www.betterbrain.com/privacy-practices Description: Review BetterBrain's Notice of Privacy Practices. Learn how we protect your health information, your rights under HIPAA, and how to access your medical records. Notice of Privacy PracticesUPDATED AND EFFECTIVE: November 19, 2025This Notice describes how health information about you may be used and disclosed and how you can get access to this information. Please review It carefully.WHO WILL FOLLOW THIS NOTICEThis Notice of Privacy Practices (this “Notice”) describes the privacy practices of Cloud Health Medical Group, P.A., Cloud Health Medical Group of California, P.C., Cloud Health Medical Group of New Jersey, P.A. Cloud Health Medical Group of Kansas, P.C., Cognitive Nutrition & Wellness LLC and Pesto Health, Inc., and our healthcare practitioners and other personnel who provide services to you (collectively, “Providers,” “we” or “us”).‍OUR PLEDGE REGARDING MEDICAL INFORMATION48824172.2We understand that your health information is personal and we are committed to protecting it. We create a record of the care and services you receive from Providers. We need this record to provide you with quality care and to comply with certain legal requirements. This Notice is required by law and applies to all of the records of your care generated us.Authority to act on behalf of the patient, if applicableThis Notice will tell you about the ways in which we may use and disclose health information about you. We also describe your rights and certain obligations we have regarding the use and disclosure of health information.______________________________________________________We are required by law to:Datemake sure that health information that identifies you is kept private (with certain exceptions);give you this Notice of our legal duties and privacy practices with respect to health information about you; follow the terms of the notice that is currently in effect; andpromptly notify you in the event of a breach of your unsecured health information.______________________________________________________HOW WE MAY USE AND DISCLOSE HEALTH INFORMATION ABOUT YOUSignatureThe following categories describe different ways that we use and disclose health information. For each category of uses or… --- ### Assignment of Benefits Source: https://www.betterbrain.com/assignment-of-benefits Description: Review BetterBrain's Assignment of Benefits agreement, including insurance payment authorization, coverage responsibilities, and billing terms. Assignment of BenefitsUPDATED AND EFFECTIVE: November 19, 2025 Agreement to PayBy signing below, I agree that:The information I am giving you is correct.Cloud Health Medical Group, P.A., Cloud Health Medical Group of California, P.C., Cloud Health Medical Group of New Jersey, P.A. Cloud Health Medical Group of Kansas, P.C., Cognitive Nutrition & Wellness LLC and Pesto Health, Inc. and their affiliated providers (collectively “Providers”) may release or share any information needed to process my claims.Providers and those providing my care shall be paid or assigned benefits on my behalf.I will cooperate with and provide documentation to my insurance company or other third-party payer as needed to process my claims.I am responsible for any costs not covered by my benefits, including non-covered services, deductibles, and co-insurance.Assignment of BenefitsI authorize and request that the payment of the proceeds of any insurance benefits for which I (or my dependent) am a beneficiary be made on my behalf directly to Providers as payment for services rendered to me. This includes any insurance company settlements related to my treatment. If my insurance company or other payer will not pay Providers directly for my care and treatment by Providers, I will immediately forward payments I receive for such care, including through a claim or lawsuit, to Providers.I also hereby irrevocably assign to Providers all benefits provided by third-party insurance payers under any policy of insurance, indemnity agreement, or any collateral source as defined by statute for services provided by Providers. This assignment includes all of my rights and interests in all such insurance benefits or proceeds for such services, including the rights to: (1) request and receive any documents or information from any entity or person, to the full extent of my rights; (2) appeal any denial or underpayment of benefits or coverage under any benefits… --- ### Telehealth Informed Consent Source: https://www.betterbrain.com/telehealth-consent Description: Review BetterBrain's telehealth informed consent covering services, privacy, provider relationships, and state-specific requirements. Telehealth Informed Consent BetterBrain Health, Inc.Last Update: May 2026In case of a medical emergency, call 911 or go to the nearest emergency department – do not rely on telehealth. Telehealth involves the use of electronic communications, information technology, or other means to enable a healthcare provider and a patient at different locations to communicate and share individual patient health information for the purpose of rendering clinical care. This “Telehealth Informed Consent” informs the patient (“patient,” “you,” or “your”) concerning the (i) treatment methods, risks, and limitations of using a telehealth platform, (ii) the means by which the healthcare providers and affiliates may communicate with you, and (iii) the assignment of benefits and your financial responsibility for the services we offer. Scope of ServicesTelehealth services are offered through BetterBrain’s affiliated healthcare providers, medical groups, and other clinical partners with which BetterBrain may contract to make telehealth services available on the platform (collectively, “Affiliated Providers”), and the Affiliated Providers’ engaged healthcare professionals (our “Providers” or your “Provider”) may include a patient consultation, diagnosis, treatment recommendation, prescription, and/or a referral to in-person care, as determined clinically appropriate (the “Services”). Your Provider will be licensed in the state where you are located at the time of your consultation, or otherwise meet a professional licensure exception under applicable state law, and will establish a provider-patient relationship in accordance with the laws and rules in the applicable state.In this Consent, "BetterBrain" refers only to the platform and administrative support entity. "Affiliated Providers" and "Providers" refer to the clinical entities and healthcare professionals responsible for clinical services. Where this Consent refers to clinical care, diagnosis, treatment, prescriptions, medical records, or provider-patient relationships, those obligations apply to the applicable Affiliated Provider or Provider, not BetterBrain.Nature of TelehealthTelehealth involves the use of electronic communications (such as video conferencing, messaging,… --- Generated by llmstxtgenerate.com