Step 01
Measure
Get the brain-specific testing your annual physical doesn't cover.
- APOE4 genetic test
- 50+ brain health biomarkers at 5,000+ Quest locations or at-home
- 15-min validated cognitive test (online)
BetterBrain combines APOE genetic testing, 50+ brain health biomarkers, and a 1-on-1 expert consultation to give you a personalized dementia prevention plan.
Coaching often covered by employer sponsored insurance
Medicare coverage coming soon







A 2024 Lancet Commission report found that 45% of dementia cases are potentially preventable by addressing modifiable risk factors.
Most risk assessments only test your genes. Ours goes further: 50+ blood biomarkers shown to raise dementia risk, cognitive assessment, and a specialist-led prevention plan tailored to you.
Step 01
Get the brain-specific testing your annual physical doesn't cover.
Step 02
Meet 1-on-1 with a brain health expert who will explain your results, and build a prevention plan that fits your biology and your life.
Step 03
Access your personal dashboard: Everything you need to act on your plan, every day, in one place.
Step 04
As your biology changes, your plan evolves with you.
The APOE4 gene is the strongest known genetic risk factor for Alzheimer's disease, backed by decades of research and thousands of studies. It affects how your brain handles cholesterol and clears amyloid plaques, and carrying one or two copies can increase your risk by 2 to 12 times compared to non-carriers.
But a gene is not a guarantee. It is a roadmap.
Getting genetic results can feel overwhelming. With BetterBrain, a brain health expert is here to help you make sense of them. You will receive your results in a personalized consultation, where they will explain what your results mean, what they imply for your brain health, and what your best next steps are.

While a specialist will go over your results with you in detail, here's how the Alzheimer's genetic test works to assess your risk.
Approx. 75% of the population

No increased genetic risk for Alzheimer's.
A negative test doesn't necessarily preclude you from getting dementia, since half of Alzheimer's patients are APOE4 negative (i.e., do not carry any APOE4 genes).
Approx. 22% of the population

Risk is 2-3 times higher compared to non-carriers.
A comprehensive and rigorous prevention plan can significantly reduce the risk for single APOE4 carriers.
Approx. 2-3% of the population

Risk is approx. 8-12 times higher compared to non-carriers.
Prevention should be even more focused and tailored to manage and monitor the risk.
Your annual physical screens for general health. We test 50+ markers tied to cognitive performance and dementia risk, then create a plan to help you improve your results.
General health screening, not designed to detect brain health risks.
Curated by our advisor panel from peer-reviewed research.
Most clients find that they are suboptimal in the additional markers we test, each connecting to a different part of your brain health.
% of clients suboptimal
Vascular health
A sharper measure of cardiovascular risk than standard cholesterol. Your brain depends on healthy vessels.
Modifiable risk
Elevated levels are linked to brain shrinkage and cognitive decline, and easily lowered with B vitamins.
Brain nutrition
Low B12 is associated with memory issues and faster cognitive aging. Easy to check, easy to fix when caught early.
Inflammation
A key marker of systemic inflammation, which drives vascular damage and accelerates cognitive decline when chronically elevated.
A cross-specialty panel of physicians and PhDs designs every part of BetterBrain, from the biomarkers we test to the protocols we recommend.
Tommy Wood, MD, PhDChief Science Officer, BetterBrainLearn moreDr. Tommy Wood is a world-leading brain health researcher and author of The Stimulated Mind. He serves as Associate Professor of Neuroscience and Pediatrics at the University of Washington, where his laboratory focuses on brain health across the lifespan. Tommy earned degrees from Cambridge (Biochemistry), Oxford (Medicine), and Oslo (PhD in Physiology and Neuroscience). Beyond his academic work, Tommy has spent over a decade as a performance consultant for professional athletes, including Olympians, world champions, and Formula 1 drivers. His book introduces the 3-S Model (Stimulus, Support, and Supply), a framework for what the brain needs to thrive at any age.
Craig Tanio, MD, FACPLearn moreDr. Tanio is trained in internal medicine, brain health, longevity, and precision medicine. As co-founder of Rezilir Health, he leads a clinical team treating complex chronic conditions such as cognitive decline, neurodegenerative disorders, Long Covid, autoimmune diseases, ME/CFS, and environmentally acquired illnesses. His approach emphasizes identifying root causes and providing practical, evidence-based care, drawing from multiple medical disciplines and aligning with patients' values and preferences. He holds a BA in Political Science from UCLA, an M.D. from UCSF, and an MBA from the Wharton School. He completed his residency and fellowship at the University of Pennsylvania, where he served as Chief Medical Resident and was a Robert Wood Johnson Clinical Scholar. Dr. Tanio is board certified in internal and functional medicine and has trained in several functional protocols. He is a co-investigator in the Evanthea Research Study, which explores reversing cognitive decline through precision medicine, and leads studies on real-world outcomes for patients with cognitive decline and ME/CFS. His leadership roles have included serving as Chief Medical Officer of ChenMed, a multi-state group practice for Medicare Advantage patients, a Partner at McKinsey & Company and Chairman of the Maryland Health Care Commission. He is also on the faculty at Johns Hopkins and Nova Southeastern University and is a member of the Alpha Omega Alpha Medical Honor Society.
Jay Saenz, MDLearn moreJay Saenz, MD, is a board-certified orthopedic surgeon and healthcare entrepreneur with over 19 years of experience in private practice. He is the Founder and President of Aethos Partners, a company dedicated to enhancing patient recovery through the integration of high-quality, innovative products into medical practices. Aethos Partners specializes in creating customized e-commerce platforms that align with the specific needs of individual practices. His company, Aethos Partners, formerly engaged in a joint venture with Obento Health, a Y Combinator-backed startup specializing in digital marketing and patient education. He now continues to contribute to Obento Health as an advisor. Additionally, his expertise has been pivotal in driving business development at OrthoSouth, where he has played a key role in establishing strategic partnerships and elevating the quality of orthopedic care in local hospitals. Dr. Saenz holds a Bachelor of Arts in Microbiology from the University of Arkansas and earned his Doctor of Medicine from the University of Arkansas for Medical Sciences. He completed his residency in Orthopedic Surgery at the University of Tennessee-Campbell Clinic and has been practicing in Memphis, TN, since 2005.
Ben Rein, PhDLearn moreDr. Ben Rein is a neuroscientist and science educator whose research focuses on the neurobiology of social interactions. He has published over 20 scientific papers about the neuroscience of empathy, the genetic basis of autism, and how brain cell communication regulates social interactions. His research has received awards from the NIH, Society for Neuroscience, and Sigma Xi. Outside the lab, Ben creates educational videos on research, neuroscience basics, and debunks misinformation for his audience of >1 million followers. His videos have received over 60 million views, been featured on major media outlets (ABC News, Good Morning America), and have won awards from the National Academies of Science, AAAS, Society for Neuroscience, and Stanford. Ben serves as Chief Science Officer of the Mind Science Foundation and is an Adjunct Lecturer at Stanford. He has been a scientific consultant for over 35 companies and foundations. He is also a contributing editor at OpenMind Magazine and the Founder of the Aspiring Scientists Coalition, an organization providing free guidance for students in 75+ countries.
“I finally have a sense of control and stopped feeling hopeless about my brain health.”
“They had the answer to every crazy question I had and the science to back it up.”
“Within 3 months, I was able to completely change my bloodwork.”
“BetterBrain helped me cut through the noise and focus on what actually works.”
“BetterBrain exceeded our expectations, 4X the information we were looking for. It changed so much in my life.”
See how genetic and biomarker testing is changing lives and drawing global headlines.
A Blood Test Accurately Diagnosed Alzheimer's 90% of the Time, Study Finds
Performance of Plasma Phosphorylated Tau 217 for Alzheimer Disease vs Clinical CSF Tests
Signs of Alzheimer's were everywhere - then his brain improved
Blood-based biomarkers for Alzheimer disease: A systematic review and meta-analysis
Blood tests for Alzheimer's disease show promise for early detection
Highly accurate blood test for Alzheimer's disease is similar or superior to clinical cerebrospinal fluid testsGet APOE4 genetic testing + comprehensive brain health assessment and personalized prevention plan