Know your dementia risk. Build a plan around it.

BetterBrain combines APOE genetic testing, 50+ brain health biomarkers, and a 1-on-1 expert consultation to give you a personalized dementia prevention plan.

  • APOE4 dementia genetic test - detect up to a 12x risk
  • Dementia biomarker test (50+ risk factors tested)
  • 1-on-1 expert consultation to interpret your results
  • Personalized dementia prevention plan built around your biology, goals and lifestyle
Get tested today

Coaching often covered by employer sponsored insurance

  • BlueCross BlueShield
  • United Healthcare
  • Aetna
  • Cigna
  • Anthem

Medicare coverage coming soon

Smiling woman in a red sweaterSmiling man in a patterned shirtSmiling woman at homeHomocysteine blood biomarker resultSauna practice cardReasoning score improvingMemory score improving

Nearly 1 in 2 dementia cases can be prevented

A 2024 Lancet Commission report found that 45% of dementia cases are potentially preventable by addressing modifiable risk factors.

Dementia risk doesn't stop at genetics. Neither do we.

Most risk assessments only test your genes. Ours goes further: 50+ blood biomarkers shown to raise dementia risk, cognitive assessment, and a specialist-led prevention plan tailored to you.

Your assessment

Biomarkers50+
APOE4Included
Cognitive test15 min

Step 01

Measure

Get the brain-specific testing your annual physical doesn't cover.

  • APOE4 genetic test
  • 50+ brain health biomarkers at 5,000+ Quest locations or at-home
  • 15-min validated cognitive test (online)
Erika, RNBrain Health ExpertWed · 90-min session

Step 02

Assess

Meet 1-on-1 with a brain health expert who will explain your results, and build a prevention plan that fits your biology and your life.

  • Up to 90 min 1-on-1 coaching session
  • Your test results, explained in plain English
  • Personalized action plan, ranked by impact
90Protocol Score3 of 12 practices
  • Strength training
  • Methylated B

Step 03

Act

Access your personal dashboard: Everything you need to act on your plan, every day, in one place.

  • Personalized practices, ranked by impact
  • Unlimited cognitive assessments to track your progress
  • SMS coach access & 24/7 AI brain coach (BeBe)

Brain Score

82

↑ +8 in 90 days

Step 04

Improve

As your biology changes, your plan evolves with you.

  • Deep dive into practices with coaching and add-on testing
  • Retest your labs to track progress
  • Follow-up coaching ($0 with insurance*)

Science you can trust. Results you can understand.

The APOE4 gene is the strongest known genetic risk factor for Alzheimer's disease, backed by decades of research and thousands of studies. It affects how your brain handles cholesterol and clears amyloid plaques, and carrying one or two copies can increase your risk by 2 to 12 times compared to non-carriers.

But a gene is not a guarantee. It is a roadmap.

Getting genetic results can feel overwhelming. With BetterBrain, a brain health expert is here to help you make sense of them. You will receive your results in a personalized consultation, where they will explain what your results mean, what they imply for your brain health, and what your best next steps are.

Backed by1000+ studies
One-time testLifelong insight
Simpleblood test
Results in4 days or less
Order your test
APOE4 genetic testing illustration

How to interpret your results

While a specialist will go over your results with you in detail, here's how the Alzheimer's genetic test works to assess your risk.

No copy of APOE4

Approx. 75% of the population

No copy of APOE4

No increased genetic risk for Alzheimer's.

A negative test doesn't necessarily preclude you from getting dementia, since half of Alzheimer's patients are APOE4 negative (i.e., do not carry any APOE4 genes).

One copy of APOE4

Approx. 22% of the population

One copy of APOE4

Risk is 2-3 times higher compared to non-carriers.

A comprehensive and rigorous prevention plan can significantly reduce the risk for single APOE4 carriers.

Two copies of APOE4

Approx. 2-3% of the population

Two copies of APOE4

Risk is approx. 8-12 times higher compared to non-carriers.

Prevention should be even more focused and tailored to manage and monitor the risk.

50+ biomarkers your annual physical doesn't test.

Your annual physical screens for general health. We test 50+ markers tied to cognitive performance and dementia risk, then create a plan to help you improve your results.

Annual Physical

  • Comprehensive Metabolic Panel
  • Complete Blood Count
  • Standard Lipid Panel
  • HbA1C
  • TSH

General health screening, not designed to detect brain health risks.

BetterBrain Blueprint

50+ markers
  • ApoB
  • Homocysteine
  • Vitamin B12
  • hsCRP
  • HbA1c
  • Lp(a)
  • Folate
  • Uric acid
  • Ferritin
  • Omega 3
  • Vitamin D
  • Insulin
  • Triglycerides
  • TSH
  • Executive Function
  • Memory
  • + 40 more brain-relevant markers

Curated by our advisor panel from peer-reviewed research.

Why these markers matter

Most clients find that they are suboptimal in the additional markers we test, each connecting to a different part of your brain health.

% of clients suboptimal

Vascular health

ApoB

86%

A sharper measure of cardiovascular risk than standard cholesterol. Your brain depends on healthy vessels.

Modifiable risk

Homocysteine

49%

Elevated levels are linked to brain shrinkage and cognitive decline, and easily lowered with B vitamins.

Brain nutrition

Vitamin B12

32%

Low B12 is associated with memory issues and faster cognitive aging. Easy to check, easy to fix when caught early.

Inflammation

hsCRP

57%

A key marker of systemic inflammation, which drives vascular damage and accelerates cognitive decline when chronically elevated.

BetterBrain's clinical advisors

A cross-specialty panel of physicians and PhDs designs every part of BetterBrain, from the biomarkers we test to the protocols we recommend.

Tommy Wood, MD, PhDTommy Wood, MD, PhDChief Science Officer, BetterBrainLearn more

Dr. Tommy Wood is a world-leading brain health researcher and author of The Stimulated Mind. He serves as Associate Professor of Neuroscience and Pediatrics at the University of Washington, where his laboratory focuses on brain health across the lifespan. Tommy earned degrees from Cambridge (Biochemistry), Oxford (Medicine), and Oslo (PhD in Physiology and Neuroscience). Beyond his academic work, Tommy has spent over a decade as a performance consultant for professional athletes, including Olympians, world champions, and Formula 1 drivers. His book introduces the 3-S Model (Stimulus, Support, and Supply), a framework for what the brain needs to thrive at any age.

Craig Tanio, MD, FACPCraig Tanio, MD, FACPLearn more

Dr. Tanio is trained in internal medicine, brain health, longevity, and precision medicine. As co-founder of Rezilir Health, he leads a clinical team treating complex chronic conditions such as cognitive decline, neurodegenerative disorders, Long Covid, autoimmune diseases, ME/CFS, and environmentally acquired illnesses. His approach emphasizes identifying root causes and providing practical, evidence-based care, drawing from multiple medical disciplines and aligning with patients' values and preferences. He holds a BA in Political Science from UCLA, an M.D. from UCSF, and an MBA from the Wharton School. He completed his residency and fellowship at the University of Pennsylvania, where he served as Chief Medical Resident and was a Robert Wood Johnson Clinical Scholar. Dr. Tanio is board certified in internal and functional medicine and has trained in several functional protocols. He is a co-investigator in the Evanthea Research Study, which explores reversing cognitive decline through precision medicine, and leads studies on real-world outcomes for patients with cognitive decline and ME/CFS. His leadership roles have included serving as Chief Medical Officer of ChenMed, a multi-state group practice for Medicare Advantage patients, a Partner at McKinsey & Company and Chairman of the Maryland Health Care Commission. He is also on the faculty at Johns Hopkins and Nova Southeastern University and is a member of the Alpha Omega Alpha Medical Honor Society.

Jay Saenz, MDJay Saenz, MDLearn more

Jay Saenz, MD, is a board-certified orthopedic surgeon and healthcare entrepreneur with over 19 years of experience in private practice. He is the Founder and President of Aethos Partners, a company dedicated to enhancing patient recovery through the integration of high-quality, innovative products into medical practices. Aethos Partners specializes in creating customized e-commerce platforms that align with the specific needs of individual practices. His company, Aethos Partners, formerly engaged in a joint venture with Obento Health, a Y Combinator-backed startup specializing in digital marketing and patient education. He now continues to contribute to Obento Health as an advisor. Additionally, his expertise has been pivotal in driving business development at OrthoSouth, where he has played a key role in establishing strategic partnerships and elevating the quality of orthopedic care in local hospitals. Dr. Saenz holds a Bachelor of Arts in Microbiology from the University of Arkansas and earned his Doctor of Medicine from the University of Arkansas for Medical Sciences. He completed his residency in Orthopedic Surgery at the University of Tennessee-Campbell Clinic and has been practicing in Memphis, TN, since 2005.

Ben Rein, PhDBen Rein, PhDLearn more

Dr. Ben Rein is a neuroscientist and science educator whose research focuses on the neurobiology of social interactions. He has published over 20 scientific papers about the neuroscience of empathy, the genetic basis of autism, and how brain cell communication regulates social interactions. His research has received awards from the NIH, Society for Neuroscience, and Sigma Xi. Outside the lab, Ben creates educational videos on research, neuroscience basics, and debunks misinformation for his audience of >1 million followers. His videos have received over 60 million views, been featured on major media outlets (ABC News, Good Morning America), and have won awards from the National Academies of Science, AAAS, Society for Neuroscience, and Stanford. Ben serves as Chief Science Officer of the Mind Science Foundation and is an Adjunct Lecturer at Stanford. He has been a scientific consultant for over 35 companies and foundations. He is also a contributing editor at OpenMind Magazine and the Founder of the Aspiring Scientists Coalition, an organization providing free guidance for students in 75+ countries.

Real clients real results

“I finally have a sense of control and stopped feeling hopeless about my brain health.”
SandraBetterBrain member since 2023
“They had the answer to every crazy question I had and the science to back it up.”
AmyBetterBrain member since 2023
“Within 3 months, I was able to completely change my bloodwork.”
KimBetterBrain member since 2023
“BetterBrain helped me cut through the noise and focus on what actually works.”
ConnorBetterBrain member since 2023
“BetterBrain exceeded our expectations, 4X the information we were looking for. It changed so much in my life.”
CaraBetterBrain member since 2023

Stay ahead with the latest in
dementia detection and prevention

APOE BetterBrain Blueprint

Get APOE4 genetic testing + comprehensive brain health assessment and personalized prevention plan

  • Brain Health Assessment50+ biomarker lab test (Quest or at-home) and a 15-minute digital cognitive test to assess brain health.
    • 50+ blood tests, many not typically covered in primary care
    • Blood panel curated by our panel of cross-speciality physicians
    • Use one of 5,000+ Quest locations, or from your home (where available)
    • 98% of appointments available next day
  • APOE4 Genetic TestingKnow your genetic risk for Alzheimer's and get personalized prevention strategies based on your DNA.
    • APOE4 (one copy): Approximately 25% of people carry 1 copy of the APOE4 variant, which increases Alzheimer's risk by 2-3 times compared to non-carriers.
    • APOE4/4 (two copies): About 2-3% of the population carries 2 copies of APOE4, which may increase risk by 8-12 times.
    • If you have the APOE4 variant, there are specific lifestyle changes that may be particularly beneficial for your brain health.
  • Up to 90 min Expert ConsultationOne-on-one session with a brain health expert to review your results.
    • Convenient online consultation from the comfort of your home - no travel or wait
    • A certified provider with a deep background in preventive neurology, all yours for 90 minutes.
    • We help you navigate the clinical and non-clinical actions to take for your brain health.
  • Personalized Brain Health PlanScience-backed plan across nutrition, exercise and more tailored to improve brain health and lower dementia risk.
    • Custom protocol based on your unique biology - tailored recommendations across nutrition, exercise, sleep, and supplements specific to your biomarkers
    • Prioritized by impact and difficulty - know exactly where to start first and what will move the needle most for your brain health
    • BetterBrain app access - daily tracking, progress monitoring, and educational content integrated into an easy-to-use dashboard
  • Unlimited Expert SupportOngoing messaging support from a dedicated coach for expert guidance and accountability.
    • Get peace of mind, anytime - from questions about your protocol to help navigating a doctor's visit. No question is too small or too tough.
    • Responses within 24 hours - our experts review your overall health, research your question, and share answers with you. All in under a day.
    • Personalized to your profile - this isn't generic advice. It's tailored support from specialists who understand your unique risk factors and goals.
  • pTau-217 TestingThe most advanced Alzheimer's blood test. Detect amyloid pathology up to 20 years before symptoms appear.+$299Optional add-on
    • We believe that pTau-217 can be a highly valuable test for anyone over 45 who wants to be proactive about their brain health. However, getting tested is a very personal choice which requires careful consideration of the benefits and drawbacks, particularly since receiving a positive ptau test can be emotionally challenging.
Traditional dementia clinics$2,000 – $10,000

BetterBrain price

With insurance$238
Cash pay$548

One-time fee

  • Money-Back Guarantee
  • HSA/FSA Eligible
  • Buy now, pay later

Lingering questions?

Schedule a free 15-minute call to explore your brain health options

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FAQs

What is the APOE gene?
APOE is a gene that affects how your brain handles cholesterol and clears amyloid plaques. Everyone has two copies of the APOE gene, creating combinations like 3/3, 3/4, or 4/4. Your combination affects your risk for Alzheimer's disease.
What do the APOE variants mean?
APOE2 is a protective variant associated with lower Alzheimer's risk. APOE3 is the most common variant, representing baseline risk. APOE4 is a higher risk variant that increases Alzheimer's likelihood. One copy of APOE4 means 2-3x higher risk. Two copies means 8-12x higher risk.
What can I do if I am an APOE4 carrier?
Key prevention strategies for APOE4 carriers include prioritizing heart-healthy fats, managing cholesterol, implementing anti-inflammatory lifestyle practices, optimizing sleep, and engaging in regular cognitive assessments. Your BetterBrain action plan will prioritize the strategies with the strongest evidence for your specific genotype.
Should I add pTau-217 testing?
If you are an APOE4 carrier, pTau-217 can be especially valuable because it tells you whether amyloid plaque buildup has started. If you are APOE4 negative, pTau-217 can still provide peace of mind, since half of Alzheimer's patients do not carry APOE4. Your brain health expert can help you decide during your consultation.
What tests are included?
Blueprint includes 50+ blood biomarkers covering metabolic, cardiovascular, hormonal, inflammation, and nutrient markers, plus a digital cognitive assessment. APOE4 genetic testing is included with Blueprint on this page. pTau-217 testing is available as an optional add-on.
What is the coaching consultation?
You will be matched with a licensed brain health clinician for a session up to 90 minutes. Together, you will go through your results and build a personalized action plan based on your biology, lifestyle, and goals.
How can I schedule my test?
Testing requires a blood draw, which you can schedule at a Quest location near you (5,000+ locations available), a BioReference lab in NY, NJ, or RI, or at home where available for an additional $50. You can complete your cognitive assessment and health profile immediately after signing up.
How will my results be delivered to me?
Your results will be shared during your consultation with a brain health expert. After the session, you will have full access to your results and personalized action plan in the BetterBrain Portal.
How do you keep my health information safe?
BetterBrain uses HIPAA-compliant systems and restricts access to your results on a need-to-know basis. Only you, the ordering physician, and your brain health expert have access to your health data.
What is your cancellation policy?
Money-back guarantee on Blueprint. If you have purchased Blueprint and are not satisfied for any reason, we will issue a 100% refund. This includes refunds even if your bloodwork has already been drawn. Refunds typically take up to two weeks to process. Appointment cancellation: if you need to reschedule or cancel your 90-minute expert session, you can do so free of charge with at least 24 hours notice. Cancellations within 24 hours of your appointment are subject to a $75 fee, which helps protect our coaches' time.
Other questions?
Feel free to contact us at contact@betterbrain.com.