Drugs · Brain health technique
Antihypertensives
Evidence grade: Context Dependent
Medications that lower blood pressure to protect vascular and brain health, including ACE inhibitors (lisinopril, enalapril), ARBs (losartan, valsartan), calcium channel blockers (amlodipine, diltiazem), thiazide diuretics (chlorthalidone, hydrochlorothiazide), and beta-blockers (metoprolol, carvedilol).
- Practice
- Drugs
- Principle
- Treatment
- Tactic
- Metabolic & Vascular Optimization Drugs
- Health domains
- vascular
- Evidence grade
- Context Dependent
- Strength of evidence
- Medium
- Cost
- High
- Effort
- Low
- Time commitment
- Low
How to practice Antihypertensives
Monitor blood pressure regularly and work with a clinician to tailor therapy. Combine medication with diet (DASH or Mediterranean), sodium reduction, and regular physical activity. Early and sustained control in midlife provides the greatest cognitive benefit. Avoid overtreatment causing hypotension, which can reduce brain perfusion.
The evidence behind Antihypertensives
Elevated blood pressure is one of the strongest modifiable risk factors for dementia and cognitive decline. Trials like SPRINT-MIND demonstrate that intensive BP control (<120 mmHg systolic) reduces mild cognitive impairment and white-matter damage. Mechanism: maintaining vascular elasticity and microvascular perfusion reduces neuronal hypoxia and inflammation. Evidence robust and consistent.
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