Supplement · Brain health technique

Glutathione

Evidence grade: Mixed / Unclear

Illustration for Glutathione

The body’s master antioxidant composed of cysteine, glycine, and glutamate. Available as oral, liposomal, or intravenous supplements, though the body normally synthesizes it from precursors.

Practice
Supplement
Principle
Nourishment
Tactic
Neuroprotective & Antioxidant Support
Evidence grade
Mixed / Unclear
Strength of evidence
Medium

How to practice Glutathione

Focus on supporting natural glutathione production through NAC (600–1,200 mg/day), vitamin C, and sulfur-rich foods (garlic, onions, crucifers). If supplementing directly, liposomal or reduced forms (250–500 mg/day) are best absorbed. Take on an empty stomach. Suitable during oxidative stress, illness, or toxin exposure.

The evidence behind Glutathione

Glutathione protects against oxidative stress and detoxifies reactive molecules. Low levels correlate with aging and neurodegeneration, but oral absorption is poor except for liposomal forms. Evidence for direct cognitive or metabolic benefit from supplementation is limited; benefits may come from precursors like NAC. Safe but often expensive relative to uncertain gain.

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