Therapy · Brain health technique
Hyperbaric Oxygen Therapy (HBOT)
Evidence grade: Experimental

Breathing 100% oxygen in a pressurized chamber (1.3–2.5 ATA) to increase tissue oxygenation and support healing or recovery from neurological and metabolic injuries.
- Practice
- Therapy
- Principle
- Treatment
- Tactic
- Physiologic & Environmental
- Evidence grade
- Experimental
- Strength of evidence
- Low
- Cost
- High
- Effort
- Medium
- Time commitment
- High
How to practice Hyperbaric Oxygen Therapy (HBOT)
Use only in medical or research settings under physician supervision. Typical protocols involve 60–90-minute sessions, 20–40 total. May benefit select individuals with brain injury or hypoxia-related conditions, but evidence remains preliminary for routine use. Avoid unregulated “wellness” chambers without medical oversight.
The evidence behind Hyperbaric Oxygen Therapy (HBOT)
HBOT has strong evidence for decompression sickness, carbon monoxide poisoning, and wound healing but remains investigational for cognitive decline, TBI, or stroke recovery. Small RCTs and Israeli studies suggest improved cerebral perfusion and cognition in mild cognitive impairment, but replication and standardization are lacking. Mechanism: enhanced oxygen delivery and stem-cell activation may support repair but risk oxidative stress if overused.
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