Supplement · Brain health technique
N-Acetylcysteine (NAC)
Evidence grade: Context Dependent
A stable form of the amino acid cysteine that boosts glutathione, the body’s main antioxidant. Also acts on glutamate and dopamine pathways relevant to mood and impulse control.
- Practice
- Supplement
- Principle
- Nourishment
- Tactic
- Neuroprotective & Antioxidant Support
- Evidence grade
- Context Dependent
- Strength of evidence
- Medium
How to practice N-Acetylcysteine (NAC)
Typical dose is 600–1,200 mg once or twice daily. Take with food to limit stomach upset. Safe for most adults, though not necessary if diet and sleep are optimal. Can be used intermittently during stress or toxin exposure, or acute immune challenges (e.g., colds). Avoid combining with nitroglycerin or high-dose antioxidants without medical guidance.
The evidence behind N-Acetylcysteine (NAC)
NAC replenishes glutathione, reducing oxidative stress and neuroinflammation. Clinical trials show benefit for certain psychiatric and addictive disorders (e.g., OCD, bipolar depression, substance use) and for colds. Cognitive benefits in healthy adults are less studied but biologically plausible. It is well tolerated but can cause mild GI discomfort. Strongest data in populations under oxidative or psychological stress.
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