Drugs · Brain health technique
Nicotinamide Riboside / NMN
Evidence grade: Experimental
NAD⁺ precursors that aim to restore cellular energy metabolism and mitochondrial function, including nicotinamide riboside (NR; Niagen®) and nicotinamide mononucleotide (NMN), both used in ongoing human longevity and neuroprotection trials.
- Practice
- Drugs
- Principle
- Treatment
- Tactic
- Emerging Longevity / Neuroregenerative Agents
- Evidence grade
- Experimental
- Strength of evidence
- Low
How to practice Nicotinamide Riboside / NMN
Only use clinical-grade formulations from verified manufacturers or within research trials. Typical studied doses: 250–1000 mg/day orally. Over-the-counter products vary in purity and stability. Safe short-term, but long-term outcomes unknown. Avoid exaggerated claims; cognitive benefits remain unproven pending phase 3 results.
The evidence behind Nicotinamide Riboside / NMN
NAD⁺ declines with age, impairing DNA repair and mitochondrial function. Supplementation with NR or NMN raises NAD⁺ levels in humans, improving markers of metabolic and vascular health. Animal models show neuroprotective effects in Alzheimer’s and ischemia, but large human RCTs have yet to demonstrate cognitive or lifespan benefit. Mechanism: enhanced NAD⁺ supports sirtuin signaling and neuronal resilience.
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