Drugs · Brain health technique
Testosterone Replacement
Evidence grade: Context Dependent
Replacement therapy for age-related or pathological hypogonadism using testosterone cypionate/enanthate injections, gels (AndroGel®, Testim®), or patches (Androderm®) to restore physiological levels.
- Practice
- Drugs
- Principle
- Treatment
- Tactic
- Hormonal Therapies
- Evidence grade
- Context Dependent
- Strength of evidence
- Medium
How to practice Testosterone Replacement
Confirm deficiency with morning total and free testosterone on two occasions before starting therapy. Target mid-normal range (400–700 ng/dL). Recheck hematocrit, PSA, and lipids every 6–12 months. Avoid supraphysiologic “performance” dosing. Benefits strongest for symptomatic men with documented low levels.
The evidence behind Testosterone Replacement
Low testosterone contributes to fatigue, depression, sarcopenia, and possibly cognitive slowing. Some studies show improved mood and motivation; evidence for cognitive benefit is mixed. Mechanism: testosterone supports synaptic plasticity, vascular tone, and neurotrophic signaling but excessive dosing can increase erythrocytosis and CV risk.
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