A BRAIN HEALTH BRIEFING · DEMENTIA RISK

Dementia risk is not just age and genes. The factors that matter most are specific to you.

There is no guaranteed way to prevent dementia. There is, however, much more you can do for your brain health than most people realize. The useful question is not how to optimize every risk factor. It is which ones matter most for you.

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Worth knowing:
The 2024 Lancet Commission identified 14 modifiable risk factors associated with dementia.
Blueprint combines 50+ biomarkers, cognition, lifestyle and family history, and a Brain Health Coach who ranks your plan by impact.
WHAT CAUSES DEMENTIA

A syndrome with several causes, not one disease.

Dementia means memory or thinking decline severe enough to interfere with daily life, and several diseases can cause it. Alzheimer's is the most common. Vascular dementia results from damage to the brain's blood supply. Lewy body and frontotemporal dementia have different underlying biology, and mixed pathology is common. The biology differs, but many of the factors associated with long-term brain health overlap.

Hearing
Blood pressure
LDL and ApoB
Blood sugar
Physical activity
READING THE LANCET NUMBER
A population estimate, not your personal odds.

The Lancet figure describes populations. It does not mean any one person can lower their risk by an exact amount. It means dementia is not driven only by age or genes: a meaningful share of population risk is connected to factors that can be changed, treated, or managed.

WHERE TO START

The list is general. The ranking is personal.

When BetterBrain looked across its coaching action plans, five recommendations appeared especially often: strength training, omega-3 intake, aerobic exercise, B vitamins, and adequate protein. That does not make them your top five.

See how coaching works ↗
WHAT THE EVIDENCE SUPPORTS
Treating hearing loss, if it is present.
Knowing your LDL and ApoB, and working with your clinician if they are elevated.
Measuring blood pressure, one of the clearest vascular factors.
Physical activity, which supports blood pressure, glucose, mood, and cognition at once.
WHAT IT DOES NOT SHOW
A guaranteed way to prevent dementia.
That any one person can lower their risk by an exact percentage.
That any one number works as a dementia test.
That the most common recommendations are automatically your top five.
WHAT TO DO WITH IT

Turn a long list into a personal plan.

Knowing that exercise, sleep, cholesterol, or blood sugar matters is not the hard part. Doing something consistently enough to change it is.

01
MEASURE
Measure the parts that can be measured.

ApoB and LDL help show atherosclerotic risk. HbA1c and fasting insulin give different views of blood sugar. hs-CRP adds context on inflammation. Homocysteine, B12, and folate may flag correctable issues.

02
INTERPRET
Rank what matters most for you.

No one number is a dementia test. Together, they show which systems are worth your attention: insulin resistance, high ApoB, or low B12 each set a different starting point.

03
ACT
Make the change consistent enough to count.

A Brain Health Coach helps translate the research into real life, work through what is getting in the way, and adjust the plan as habits, goals, and biology change.

IF WE RECOMMEND IT, YOU CAN SEE THE SCIENCE

Science-backed should mean you can see the science.

BetterBrain has mapped roughly 1,500 studies to the biomarkers and techniques inside the app. When your plan includes strength training, a sleep technique, nutrition changes, or a biomarker target, you can see the research used to support it.

See what BetterBrain tests ↗
~1,500
studies mapped to the biomarkers and techniques in the app
14
modifiable risk factors named by the 2024 Lancet Commission
BEFORE YOU WORK THROUGH ANOTHER LIST

Know what your plan is built on.

A general list of risk factors applies to everyone. Your starting point depends on your own markers, cognition, lifestyle, and family history.

COMMON APPROACH
A generic risk-factor checklist
COMMON APPROACH
One lab value in isolation
BETTERBRAIN'S PANEL · SELECTED
Your own ranking, in 50+ marker context
What the selected measure tells you, and what surrounds it here.

Blueprint includes 50+ biomarkers, cognitive testing, lifestyle and family-history context, and a personalized plan ranked by impact. When your plan includes a recommendation, you can see the research used to support it.

THE BETTERBRAIN APPROACH

Information is one input. The plan is the product.

BetterBrain does not hand you a number and wish you luck. Every result is read inside a system built to explain what it means for you, and where you can take meaningful action.

OUR SYSTEM
14 FACTORS · YOUR PRIORITIES
01
50+ biomarkers
02
Cognitive baseline
03
Health context and lifestyle
04
Expert review
05
Personalized plan
45%
of dementia cases are potentially preventable, at the upper estimate
PATHOLOGY IS NOT THE WHOLE STORY

There is more to brain health than one checklist.

Up to 45% of dementia cases are potentially preventable, according to the 2024 Lancet Commission, which identified 14 modifiable risk factors across life. The useful question is where your own margin lies.

Review the evidence ↗
QUESTIONS PEOPLE ASK FIRST

Clear answers, without false certainty.

Not with certainty. But many important risk factors are modifiable, and addressing them is associated with lower dementia risk at the population level.

Alzheimer's disease is the most common cause. Among modifiable risk factors, hearing loss is one of the largest contributors in the 2024 Lancet analysis.

Current evidence does not support that conclusion. If you take a statin, do not stop it because of a blog post. Discuss questions with your clinician.

Midlife is particularly important because vascular and metabolic risk accumulates over decades. But starting later still matters.

Find where your own margin lies, then start there.

Blueprint reads 50+ biomarkers alongside cognitive testing, lifestyle, and family history. A Brain Health Coach turns them into a personalized action plan, ranked by impact, and helps you follow through.

Book a BetterBrain coaching session
$0 with insurance for eligible clients. We check coverage first, no card needed.