Moderate Toxins · Brain health technique
Consider risks of Proton pump inhibitors (PPIs)
Evidence grade: Mixed / Unclear
Stomach-acid blockers like omeprazole (Prilosec) and esomeprazole (Nexium).
- Practice
- Moderate Toxins
- Principle
- Protection
- Tactic
- Minimize Medications And Substances That Damage The Brain
- Evidence grade
- Mixed / Unclear
- Strength of evidence
- Medium
- Cost
- Low
- Effort
- Low
- Time commitment
- Low
How to practice Consider risks of Proton pump inhibitors (PPIs)
Use the lowest effective dose for the shortest time. For chronic reflux, review need yearly and check B12 levels. Short courses appear safe. Speak with your physician about potential alternatives.
The evidence behind Consider risks of Proton pump inhibitors (PPIs)
Some observational studies show long-term use (> 3 years) associates with higher dementia risk, possibly from vitamin B12 deficiency or microbiome changes. However, large recent trials haven’t confirmed a direct cause.
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