Moderate Toxins · Brain health technique
Corticosteroids (long-term systemic use)
Evidence grade: Context Dependent

Prednisone, dexamethasone, and similar drugs taken by mouth or injection for inflammation.
- Practice
- Moderate Toxins
- Principle
- Protection
- Tactic
- Minimize Medications And Substances That Damage The Brain
- Evidence grade
- Context Dependent
- Strength of evidence
- Medium
How to practice Corticosteroids (long-term systemic use)
For chronic conditions, use the lowest dose for the shortest time, explore local treatments (inhaled, topical) or non-steroid options when feasible.
The evidence behind Corticosteroids (long-term systemic use)
Long-term systemic steroids can cause mood changes, insomnia, and memory problems, and may shrink the hippocampus through cortisol overload. Short bursts for asthma or autoimmune flares are safe and sometimes life-saving.
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